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Immunological and biochemical characterisation of type C viruses isolated from cultured human AML cells

Abstract

TYPE C viruses are associated in several species with naturally occurring malignancy and have been isolated from a variety of species including several non-human primates. The ability to specify interviral relationships is crucial for evaluating the degree of relatedness of new isolates to known viruses, especially those which are potentially associated with human malignancy. Recent studies of Gallagher and Gallo1 indicated the presence of a type C virus in cultured cells from a patient with acute myelogenous leukaemia (AML) (patient A.S.). Viruses from this culture have been propagated in homologous and heterologous fibroblastic cells2 in sufficient quantity to be characterised in detail.

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OKABE, H., GILDEN, R., HATANAKA, M. et al. Immunological and biochemical characterisation of type C viruses isolated from cultured human AML cells. Nature 260, 264–266 (1976). https://doi.org/10.1038/260264a0

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