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α-Chain contacts in the polymerization of sickle haemoglobin

Nature volume 260, pages 219–221 (1976)Cite this article

Abstract

Five new double-mutant haemoglobins composed of βs chains and α chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to evaluate several regions on the α chains for intermolecular contacts in the polymerisation of deoxyhaemoglobin S.

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Authors and Affiliations

  1. Department of Biochemistry, Columbia University, College of Physicians and Surgeons, New York, New York, 10032

    Ruth E. Benesch, Suzanna Yung, Reinhold Benesch & John Mack

  2. Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, 77550

    Rose G. Schneider

Authors
  1. Ruth E. Benesch
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  2. Suzanna Yung
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  3. Reinhold Benesch
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  4. John Mack
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  5. Rose G. Schneider
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Benesch, R., Yung, S., Benesch, R. et al. α-Chain contacts in the polymerization of sickle haemoglobin. Nature 260, 219–221 (1976). https://doi.org/10.1038/260219a0

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