Abstract
THYMUS-derived (T) cells have a major role in immune systems. They mediate various functions, such as T–B cooperation (‘helper cells’)1 and the mixed lymphocyte reaction2, become killer cells3, are active in graft versus host responses (reviewed in ref. 4) and act as suppressor cells5. The identification of the cells responsible for these functions as T cells was facilitated by the use of antisera against the T-cell-specific alloantigen, Thy-1 (ref. 6) (formerly known as θ). It has been reported that Ly allo-antigens, present exclusively on T cells7, identify functionally distinct subpopulations of T cells8. For example, T helper cells were lysed by anti-Ly–1, but not by anti-Ly–2, so that their phenotype is Ly–1+2−, whereas T killer cells were a distinct subpopulation, being Ly–1−2+. We report here that specific T suppressor cells induced in vitro have a different Ly alloantigen phenotype from T helper cells induced in vitro from the same spleen cell pool.
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FELDMANN, M., BEVERLEY, P., DUNKLEY, M. et al. Different Ly antigen phenotypes of in vitro induced helper and suppressor cells. Nature 258, 614–616 (1975). https://doi.org/10.1038/258614a0
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DOI: https://doi.org/10.1038/258614a0
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