Abstract
The nucleotide coenzyme cytidine-5′-diphospho-choline is highly folded. The CMP-5′ parts of the molecules in the crystal structure are strongly linked by metal ligation and hydrogen bonds leaving the phosphoryl-choline residues relatively free. Cytidine-5′-diphosphoric acid exists as a zwitterion with N31 protonated. The P–O bond lengths from the anhydride bridging oxygen in the pyrophosphate are significantly different.
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Viswamitra, M., Seshadri, T., Post, M. et al. Molecular structures of cytidine-5′-diphosphate and cytidine-5′-diphospho-choline, and their role in intermediary metabolism. Nature 258, 497–501 (1975). https://doi.org/10.1038/258497a0
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DOI: https://doi.org/10.1038/258497a0
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