Abstract
A β-ADRENERGIC receptor coupled to adenylate cyclase regulates the activity of rat pineal N-acetyltransferase, an enzyme involved in the biosynthesis of melatonin1. At the onset of darkness there is an increase in the release of the neurotransmitter noradrenaline from sympathetic nerves2,3 which produces 30- to 50-fold increases in N-acetyltransferase activity4. During periods of exposure to light, nerve activity and noradrenaline turnover are lower than during peribds of darkness2,3, and N-acetyltransferase activity remains at its lowest level4.
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ROMERO, J., ZATZ, M., KEBABIAN, J. et al. Circadian cycles in binding of 3H-alprenolol to β-adrenergic receptor sites in rat pineal. Nature 258, 435–436 (1975). https://doi.org/10.1038/258435a0
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DOI: https://doi.org/10.1038/258435a0
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