Abstract
ALTHOUGH several cell types derived from biopsies of patients with Hodgkin's disease have been grown in vitro1,2, there has been no convincing experimental evidence for the identity and origin of such cells. We wish to present data demonstrating clonal and continuous proliferation of Hodgkin cells, their relationship to Reed–Sternberg cells and their probable origin from B lymphocytes.
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References
Peckham, M. J., and Cooper, E. H., Natn. Cancer Inst. Monogr., 36, 179–189 (1973).
Nilsson, K., and Pontén, J., Int. J. Cancer, 15, 321–341 (1975).
Boyum, A., Boecker, W. R., Carsten, A. L., and Cronkite, E. P., Blood, 40, 163–173 (1972).
Boecker, W. R., et al., in Hemopoiesis in Culture (edit. by Robinson, W. A.), 446–450 (US Government Printing Office, Washington DC, 1974).
Reedman, B. M., and Klein, G., Int. J. Cancer, 11, 499–520 (1973).
Sandberg, A. A., and Hossfeld, D. K., in Handbuch der allgemeinen Pathologie, 6 (edit. by Grundmann, E.), 5–6, 141–287 (Springer, Berlin–Heidelberg–New York, 1974).
Hossfeld, D. K., Humangenetik, 23, 111–118 (1974).
Fröland, S., Natvig, J. B., and Berdal, P., Nature new Biol., 234, 251–252 (1971).
Jondal, M., Holm, G., and Wigzell, H., J. exp. Med., 136, 207–215 (1972).
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BOECKER, W., HOSSFELD, D., GALLMEIER, W. et al. Clonal growth of Hodgkin cells. Nature 258, 235–236 (1975). https://doi.org/10.1038/258235a0
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DOI: https://doi.org/10.1038/258235a0
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