Abstract
IN both experimentally infected animals1,2 and in asymptomatic human subjects3,4 herpes simplex virus (HSV) can establish a latent infection in the sensory ganglia of the nervous system. It is probably the periodic reactivation of virus within these ganglia that gives rise to recurrent herpetic eruptions on epithelial surfaces innervated by the infected ganglia. The ganglia of the peripheral autonomic nervous system seem to share a common embryogenesis with sensory ganglia5. Although it has been shown that acute infection of autonomic ganglia with HSV6 and the related herpesvirus, pseudorabies virus7–9, can occur, it has not been established that the peripheral autonomic nervous system (ANS) can support a latent infection with these or other viruses. We report here a marine model of latent infection of the superior cervical ganglion (SCG) of the sympathetic division of the ANS.
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PRICE, R., KATZ, B. & NOTKINS, A. Latent infection of the peripheral ANS with herpes simplex virus. Nature 257, 686–688 (1975). https://doi.org/10.1038/257686a0
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DOI: https://doi.org/10.1038/257686a0
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