Abstract
ANTIBODIES which react with bound complement components, in particular the third component C3, have been found in the parotid saliva of most normal subjects1. These antibodies have several unusual properties2. Their binding to complement is dependent on calcium ions, they can be inhibited by small amounts of native C3 and although they belong to the IgA class they are macromolecules with a sedimentation coefficient greater than 19S. The titres in mixed saliva are substantially lower than in parotid saliva1 and the reduction in titre results from the presence of C3 in mixed saliva that combines with the antibody and neutralises its activity. While investigating the possibility that crevicular fluid was the source of C3 in the mouth, we examined samples of saliva from newborn babies. High antibody titres were found in these samples. We report here on the prevalence and properties of this antibody in neonatal saliva.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Williams, B. D., Challacombe, S. J., Slaney, J. M., Lachmann, P. J., and Lehner, T., Clin. exp. Immun., 19, 423 (1975).
Lachmann, P. J., and Thomson, R. A., Immunology, 18, 157 (1970).
West, C. D., Davies, N. C., Fornistal, J., Herbst, J., and Spitzer, R., J. Immun., 96, 650 (1966).
Selner, J. C., Merrill, D. A., and Claman, H. N., J. Paediatrics, 72, 685 (1968).
Tom asi, T. B., and Bienenstock, J., Adv. Immun., 9, 2 (1968).
Challacombe, S. J., Caries Res. (in the press).
Lachmann, P. J., Elias, D. E., and Moffett, A., in Biological Activities of Complement (edit. by Ingram, D. G.) (Karger, Basel, 1972).
McCarthy, C., Snyder, M. C., and Parker, R. B., Archs oral. Biol., 10, 61 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PRICE, J., WILLIAMS, B. & CHALLACOMBE, S. Anti-C3 antibodies in neonatal saliva. Nature 257, 146–147 (1975). https://doi.org/10.1038/257146a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/257146a0
This article is cited by
-
The early postnatal development of salivary antibody and immunoglobulin response in children orally colonized with a nonpathogenic, probiotic strain ofE. coli
Folia Microbiologica (2003)
-
Agglutinins for complement-coated sheep erythrocytes
Nature (1976)
-
Classical pathway activation of complement system by IgA anti-C3 antibody
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.