Abstract
COLLIER and Roy1 have proposed that in morphine-sensitive neurones the receptor site may be adenyl cyclase, which is physiologically stimulated by prostaglandin E1 (PGE1) and pharmacologically blocked by opiates. An hypothesis has been put forward that morphine exerts its analgesic effect by inhibiting the stimulation by PGE1 of cyclic AMP formation in appropriate neurones2, whereas acute side effects of opiates may be caused by stimulation of prostaglandin biosynthesis3.
Access options
Subscribe to Journal
Get full journal access for 1 year
220,50 €
only 4,32 € per issue
All prices include VAT for France.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1.
Collier, H. O. J., and Roy, A. C., Nature, 248, 24–27 (1974).
- 2.
Collier, H. O. J., and Roy, A. C., Prostaglandins, 7, 361–376 (1974).
- 3.
Collier, H. O. J., McDonald-Gibson, W. J., and Saeed, S. A., Nature, 252, 56–58 (1974).
- 4.
Shio, H., Shaw, J., and Ramwell, P., Ann. N.Y. Acad. Sci., 185, 327–335 (1971).
- 5.
Bruno, J. J., Taylor, L. A., and Droller, M. J., Nature, 251, 721–723 (1974).
- 6.
Srivastava, K. C., and Clausen, J., Lipids, 7, 762–765 (1972).
- 7.
Hamberg, M., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 71, 3400–3405 (1974).
- 8.
Born, G. V. R., Nature, 194, 927–929 (1962).
- 9.
Han, P., and Ardlie, N. G., Br. J. Haemat., 26, 373–389 (1974).
- 10.
Feldberg, W., and Paton, W. D. M., J. Physiol., Lond., 114, 490–509 (1951).
- 11.
Lichtenstein, L. M., in Asthma (edit. by Austen, K. F., and Lichtenstein, L. M.), 91–103 (Academic, New York and London, 1973).
- 12.
Albro, P., Thomas, R., and Fishbein, L., Prostaglandins, 1, 133 (1972).
- 13.
Goldstein, A., Life Sci., 14, 615–623 (1974).
Author information
Affiliations
Departments of Pharmacology and Allergy, and Clinical Immunology, Copernicus Academy of Medicine in Cracow, 31–531 Cracow, 16 Grzegórzecka, Poland
- RYSZARD J. GRYGLEWSKI
- , ANDRZEJ SZCZEKLIK
- & KRZYSZTOF BIERON
Authors
Search for RYSZARD J. GRYGLEWSKI in:
Search for ANDRZEJ SZCZEKLIK in:
Search for KRZYSZTOF BIERON in:
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
