Abstract
BOTH noradrenaline (NA) and dopamine are able to stimulate the synthesis of cyclic AMP in brain tissues in vitro1,2. Furthermore, several iontophoretic studies have indicated that the hyperpolarisation elicited by catecholamines in cerebellum3, hippocampus4, striatum5 and cortex6 is mediated by cyclic AMP, suggesting that this nucleotide may act as a second messenger for some actions of the catecholamines at central synapses.
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References
Forn, J., Krueger, B. K., and Greengard, P., Science, 186, 1118–1120 (1974).
Von Hungen, K., and Roberts, S., Eur. J. Biochem., 36, 391–401 (1973).
Hoffer, B. J., Siggins, G. R., Oliver, A. P., and Bloom, F. E., in Advances in Cyclic Nucleotide Research, 1 (edit. by Greengard, P., and Robison, G. A.), 411–423 (Raven, New York, 1972).
Segal, M., and Bloom, F. E., Brain Res., 72, 79–97 (1974).
Siggins, G. R., Hoffer, B. J., and Ungerstedt, U., Life Sci., 15, 779–792 (1974).
Stone, T. W., Taylor, D. A., and Bloom, F. G., Science, 187, 845–847 (1975).
Kalisker, A., Rutledge, C. O., and Perkins, J. P., Molec. Pharmac., 9, 619–629 (1973).
Mishra, R. K., Gardner, E. L., Katzman, R., and Makman, M. H., Proc. natn., Acad. Sci. U.S.A., 71, 3883–3887 (1974).
Dismukes, K., and Daly, J. W., Molec. Pharmac., 10, 933–940 (1974).
Glowinski, J., and Baldessarini, R. J., Pharmac. Rev., 18, 1201–1238 (1966).
Baudry, M., Martres, M. P., and Schwartz, J. C., Nature, 253, 362–363 (1975).
Schultz, J., and Daly, J. W., J. Neurochem., 21, 1319–1326 (1973).
Skolnick, P., and Daly, J. W., J. Neurochem., 24, 451–456 (1975).
Schultz, J., and Daly, J. W., J. biol. Chem., 248, 860–866 (1973).
De Vellis, J., and Brooker, G., Science, 186, 1221–1223 (1974).
Perkins, J. P., in Advances in Cyclic Nucleotide Research, 3, (edit. by Greengard, P., and Robison, G. A.), 1–64 (Raven, New York, 1973).
Deguchi, T., and Axelrod, J., Proc. natn. Acad. Sci. U.S.A., 70, 2411–2414 (1973).
Romero, J. A., and Axelrod, J., Science, 184, 1091–1092 (1974).
Brodie, B. B., Cho, A. K., and Gessa, G. L., in Proc. Int. Symp. Amphetamines related compounds (edit. by Costa, E., and Garattini,S.), 217–230 (Raven, New York, 1970).
Lewander, T., Psychopharmacologia, Berl., 21, 17–31 (1971).
Kalant, H., Leblanc, A. E., and Gibbins, R. J., Pharmac. Rev., 23, 135–191 (1971).
Thierry, A. M., Blanc, G., Sobel, A., Stinus, L., and Glowinski, J., Science, 182, 499–501 (1973).
Tonge, S. R., Psychopharmacologia, Berl., 38, 181–186 (1974).
Jönsson, L. E., and Gunne, L. M., in Proc. Int. Symp. Amphetamines related compounds, (edit. by Costa, E., and Garattini, S.), 929–936 (Raven, New York 1970).
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MARTRES, MP., BAUDRY, M. & SCHWARTZ, JC. Subsensitivity of noradrenaline-stimulated cyclic AMP accumulation in brain slices of d-amphetamine-treated mice. Nature 255, 731–733 (1975). https://doi.org/10.1038/255731a0
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DOI: https://doi.org/10.1038/255731a0
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