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Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides

Nature volume 255, pages 378–382 (1975)Cite this article

Abstract

The binding of concanavalin A to T but not B mouse spleen lymphocytes increases Ca2+ uptake in these cells which is measurable by 45 s and complete by 1 min. Dibutyryl cyclic AMP, but not sodium azide inhibits induced Ca2+ uptake, whereas dibutyryl cyclic GMP enhances it. B cell mitogens do not cause a similar Ca2+ uptake in mouse B lymphocytes. The induction of increased Ca2+ uptake by T cells is discussed in terms of gated membrane channels for Ca2+.

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Authors and Affiliations

  1. MRC Neuroimmunology Project, Department of Zoology, University College London, London, WC1E 6BT, UK

    Murray H. Freedman & Martin C. Raff

  2. Department of Experimental Pathology, University College Hospital Medical School, London, WC1E 6JJ, UK

    Bastien Gomperts

Authors
  1. Murray H. Freedman
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  2. Martin C. Raff
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  3. Bastien Gomperts
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Freedman, M., Raff, M. & Gomperts, B. Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides. Nature 255, 378–382 (1975). https://doi.org/10.1038/255378a0

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  • DOI: https://doi.org/10.1038/255378a0

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