Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse

Abstract

THYMUS-DERIVED lymphocytes (T cells) have several functions1–3, and in some instances it appears that two sub-populations of T cells interact to amplify their response4,5. But recognition of the diverse functions and interactions of T cells has not been matched by the development of techniques for identifying and separating the different T-cell subpopulations involved. The ability to do so would greatly aid study of the many roles of T cells. We report here experiments with mice that show that antisera to different Ly alloantigens can identify functionally-distinct subpopulations of T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cantor, H., Prog. Biophys. molec. Biol., 25. 73–81 (1972).

    Article  CAS  Google Scholar 

  2. Greaves, M. F., and Janossy, G., Transplant. Rev., 11, 87–130 (1972).

    CAS  PubMed  Google Scholar 

  3. Raff, M. C., Nature, 226, 1257–1258 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Cohen, L., and Howe, M. L., Proc. natn. Acad. Sci. U.S.A., 70, 2707–2710 (1973).

    Article  ADS  CAS  Google Scholar 

  5. Cantor, H., and Asofsky, R., J. exp. Med., 135, 764–779 (1972).

    Article  CAS  Google Scholar 

  6. Boyse, E. A., Miyazawa, M., Aoki, T., and Old, L. J., Proc. R. Soc., B 170, 175–193 (1968).

    ADS  CAS  Google Scholar 

  7. Scheid, M., Boyse, E. A., Carswell, E. A., and Old, L. J., J. exp. Med., 135, 938–955 (1972).

    Article  CAS  Google Scholar 

  8. Boyse, E. A., Bressler, E., Iritani, C. A., and Lardis, M., Transplantation, 9, 339–340 (1970).

    Article  Google Scholar 

  9. Boyse, E. A., Old, L. J., and Chouroulinkov, I., Methods med. Res., 10, 39–47 (1964).

    CAS  PubMed  Google Scholar 

  10. Shiku, H., Kisielow, P., Bean, M. A., Takahashi, T., Boyse, E. A., Oettgen, H. F., and Old, L. J., J. exp. Med. (in the press).

  11. Kettman, J., and Dutton, R. W., J. Immun., 104, 1558–1561 (1970).

    CAS  PubMed  Google Scholar 

  12. Hoffman, M., and Kappler, J. W., J. exp. Med., 137, 721–739 (1973).

    Article  Google Scholar 

  13. Bean, M. A., Pees, H., Rosen, G., and Oettgen, H. F., Natn. Cancer Inst. Monog., 37, 41–48 (1973).

    CAS  Google Scholar 

  14. Shiku, M., Bean, M. A., Old, L. J., and Oettgen, H. F., J. natn. Cancer Inst. (in the press).

  15. Simonsen, M., Prog. Allergy, 6, 349–467 (1962).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

KISIELOW, P., HIRST, J., SHIKU, H. et al. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature 253, 219–220 (1975). https://doi.org/10.1038/253219a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/253219a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing