Abstract
THYMUS-DERIVED lymphocytes (T cells) have several functions1–3, and in some instances it appears that two sub-populations of T cells interact to amplify their response4,5. But recognition of the diverse functions and interactions of T cells has not been matched by the development of techniques for identifying and separating the different T-cell subpopulations involved. The ability to do so would greatly aid study of the many roles of T cells. We report here experiments with mice that show that antisera to different Ly alloantigens can identify functionally-distinct subpopulations of T cells.
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References
Cantor, H., Prog. Biophys. molec. Biol., 25. 73–81 (1972).
Greaves, M. F., and Janossy, G., Transplant. Rev., 11, 87–130 (1972).
Raff, M. C., Nature, 226, 1257–1258 (1970).
Cohen, L., and Howe, M. L., Proc. natn. Acad. Sci. U.S.A., 70, 2707–2710 (1973).
Cantor, H., and Asofsky, R., J. exp. Med., 135, 764–779 (1972).
Boyse, E. A., Miyazawa, M., Aoki, T., and Old, L. J., Proc. R. Soc., B 170, 175–193 (1968).
Scheid, M., Boyse, E. A., Carswell, E. A., and Old, L. J., J. exp. Med., 135, 938–955 (1972).
Boyse, E. A., Bressler, E., Iritani, C. A., and Lardis, M., Transplantation, 9, 339–340 (1970).
Boyse, E. A., Old, L. J., and Chouroulinkov, I., Methods med. Res., 10, 39–47 (1964).
Shiku, H., Kisielow, P., Bean, M. A., Takahashi, T., Boyse, E. A., Oettgen, H. F., and Old, L. J., J. exp. Med. (in the press).
Kettman, J., and Dutton, R. W., J. Immun., 104, 1558–1561 (1970).
Hoffman, M., and Kappler, J. W., J. exp. Med., 137, 721–739 (1973).
Bean, M. A., Pees, H., Rosen, G., and Oettgen, H. F., Natn. Cancer Inst. Monog., 37, 41–48 (1973).
Shiku, M., Bean, M. A., Old, L. J., and Oettgen, H. F., J. natn. Cancer Inst. (in the press).
Simonsen, M., Prog. Allergy, 6, 349–467 (1962).
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KISIELOW, P., HIRST, J., SHIKU, H. et al. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature 253, 219–220 (1975). https://doi.org/10.1038/253219a0
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DOI: https://doi.org/10.1038/253219a0
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