Abstract
THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.
Access options
Subscribe to Journal
Get full journal access for 1 year
220,50 €
only 4,32 € per issue
All prices include VAT for France.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1.
Ball, G., Brereton, G. G., Fulwood, M., Ireland, D. M., and Yates, P., Biochem. J., 120, 709–718 (1970).
- 2.
Mills, D. C. B., and Smith, J. B., Biochem. J., 121, 185–196 (1971).
- 3.
Kloeze, J., in Prostaglandins (edit. by Bergstrom, S. and Samuelsson, B.) 241–252 (Almquist and Wiksell, Stockholm, 1967).
- 4.
Salzman, E. W., New Engl. J. Med., 286, 358–363 (1972).
- 5.
Smith, J. B., and Willis, A. L., Nature new Biol., 231, 235–237 (1971).
- 6.
Droller, M. J., Proc. 15th Mtg Am. Soc. Hematol. (1972).
- 7.
Born, G. V. R., J. Physiol., Lond., 162, 67P–68P (1962).
- 8.
Hirsh, J., Street, D., Cade, J. F., and Amy, H., Blood, 41, 369–377 (1973).
- 9.
Haslam, R. J., Nature, 202, 765–768 (1964).
- 10.
Wolfe, S. M., and Shulman, N. R., Biochem. biophys. Res. Commun., 35, 265–272 (1969).
- 11.
White, A. A., and Zenser, T. V., Analyt. Biochem., 41, 372–396 (1971).
- 12.
Ramachandran, J., Analyt. Biochem., 43, 227–239 (1971).
- 13.
Droller, M. J., and Wolfe, S. M., J. clin. Invest., 51, 3094–3103 (1972).
- 14.
Shio, H., and Ramwell, P. W., Nature new Biol., 236, 45–46 (1972).
- 15.
Droller, M. J., and Wolfe, S. M., New Engl. J. Med., 286, 948 (1972).
Author information
Affiliations
Syntex Research, Institute of Biological Sciences, Palo Alto, California 94304
- JOHN J. BRUNO
- & LESLIE A. TAYLOR
Stanford University Medical Center, Stanford, California 94305
- MICHAEL J. DROLLER
Authors
Search for JOHN J. BRUNO in:
Search for LESLIE A. TAYLOR in:
Search for MICHAEL J. DROLLER in:
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
