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Pronounced antiviral activity of human interferon on bovine and porcine cells

Abstract

INTERFERONS prepared from cells of one species may exhibit some activity on cells of others although the titre on heterologous cells is usually considerably lower than that for homologous cells1. The one exception to date has been the finding that human fibroblast interferon was far more active on heterologous rabbit cells than on human cells2,3. We report here that human leukocyte and fibroblast interferon preparations exert a pronounced antiviral activity on bovine and porcine cells, and the activity of the human leukocyte interferon is far greater on heterologous bovine cells than on homologous human or monkey cells.

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GRESSER, I., BANDU, MT., BROUTY-BOYE, D. et al. Pronounced antiviral activity of human interferon on bovine and porcine cells. Nature 251, 543–545 (1974). https://doi.org/10.1038/251543a0

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