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Dissociation of lymphocyte activating determinants from recognition sites in mouse MLR

Nature volume 251, pages 227–229 (1974)Cite this article

Abstract

PREVIOUSLY, we were able to block mixed lymphocyte reactions (MLR) in man using anti-light chain antibody1 but we have been unable to confirm this observation in subsequent studies using other anti-light chain sera. We have now found that MLR in the mouse is unaffected by a variety of anti-immunoglobulin sera but using alloantisera it has become evident that the stimulator cells, but not the responder lymphocytes, can be blocked.

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Author information

Authors and Affiliations

  1. Tissue Immunology Unit, London Hospital Medical College, London, E1, UK

    KUDSIA ABBASI & HILLIARD FESTENSTEIN

  2. Department of Immunology, Middlesex Hospital Medical School, London, W1, UK

    WINSTON VERBI & IVAN M. ROITT

Authors
  1. KUDSIA ABBASI
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  2. HILLIARD FESTENSTEIN
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  3. WINSTON VERBI
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  4. IVAN M. ROITT
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ABBASI, K., FESTENSTEIN, H., VERBI, W. et al. Dissociation of lymphocyte activating determinants from recognition sites in mouse MLR. Nature 251, 227–229 (1974). https://doi.org/10.1038/251227a0

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