Abstract
MAMMALIAN embryonic haemoglobins are synthesised in nucleated erythroid cells derived from the yolk sac1. They are structurally different from foetal and adult haemoglobins. It has been generally assumed that the difference of embryonic to foetal or adult haemoglobin is solely due to an embryonic globin chain structurally related to the β chain. It was believed that embryos either synthesise no α-type chain at all or an α chain structurally identical to the adult α chain2,3.
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MELDERIS, H., STEINHEIDER, G. & OSTERTAG, W. Evidence for a unique kind of α-type globin chain in early mammalian embryos. Nature 250, 774–776 (1974). https://doi.org/10.1038/250774a0
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DOI: https://doi.org/10.1038/250774a0
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