Abstract
THE high incidence of spontaneous leukaemias in AKR mice may be explained by the early appearance and high level of replication of a type C virus. It is often suggested, however, that in addition, AKR mice could be tolerant to their leukaemias. This tolerance would enhance the in vivo growth of malignant cells. In fact, AKR mice are not completely devoid of antileukaemic immune response1–5. It would be interesting, therefore, to determine if a quantitative or qualitative defect of one given type of antileukaemic response exists in AKR mice. Previous work has shown that an antibody response directed against the type C virus or against antigens of leukaemic cells can be demonstrated not only in hyperimmune1 but also in normal AKR mice4. A cell mediated reaction directed against G (Gross)6 leukaemia antigen-bearing cells was also detected in vitro5,7 but this cell-mediated reaction was characterised by inhibition of the growth of G+ cells in monolayers. It is now known, however, that this kind of inhibition can be due to non-T cells7–9 and could be antibody dependent10. A completely different cell-mediated antitumour reaction can be evidenced in the murine sarcoma virus (MSV) induced tumour system by the chromium release test (CRT) which detects a pure T-cell-mediated11,12 and antibody-independent13 cytolysis of tumour cells. Our work was performed to determine if AKR mice are capable of spontaneously developing such a kind of T-killer cell response.
Similar content being viewed by others
Article PDF
References
Doré, J. F., Ajuria, E., and Mathé, G., Revue Étud. clin. biol., 15, 81–84 (1970).
Marklam, R. V., Sutherland, J. C., Cimino, E., Drake, W. P., and Mardiney, M. R., Revue Étud. clin. biol., 17, 690–698 (1972).
Vredevoe, D. L., and Hays, E. F., Cancer Res., 29, 1685–1690 (1969).
Oldstone, M. A., Aoki, A., and Dixon, F. J., Proc. natn. Acad. Sci U.S.A., 69, 134–138 (1972).
Wahren, B., and Metcalf, D., Clin. exp. Immun., 7, 373–386 (1970).
Old, L. J., Boyse, E. A., and Stockert, E., Cancer Res., 25, 813–819 (1965).
Lamon, E. W., Skurzak, H. M., Klein, E., and Wigzell, H., J. exp. Med., 136, 1072–1079 (1972).
Plata, F., Gomard, E., Leclerc, J. C., and Levy, J. P., J. Immun., 112, 1477–1487 (1974).
Owen, J. J. T., and Seeger, R. C., Br. J. Cancer, 28, Suppl. I, 26–34 (1973).
Baldwin, R. W., Price, M. R., and Robins, R. A., Int. J. Cancer, 11, 527–535 (1973).
Leclerc, J. C., Gomard, E., Plata, F., and Levy, J. P., Int. J. Cancer, 11, 426–432 (1973).
Plata, F., Gomard, E., Leclerc, J. C., and Levy, J. P., J. Immun., 111, 667–671 (1973).
Leclerc, J. C., Gomard, E., and Levy, J. P., Int. J. Cancer, 10, 589–601 (1972).
Ortiz de Landazuri, M., and Herbermann, R. B., Nature new Biol., 238, 18–19 (1972).
Cerottini, J. C., Nordin, A. A., and Brunner, K. T., Nature, 228, 1308–1309 (1970).
Golstein, P., Shirrmacher, U., Rubin, B., and Wigzell, H., Cell. Immun., 9, 211–225 (1973).
Wigzell, H., Sundqvist, K. G., and Yoshida, T. O., Scand. J. Immun., 1, 75–87 (1972).
Greenberg, A. H., and Playfair, J. M. L., Clin. exp. Immun., 16, 99–110 (1974).
Lilly, F., Boyse, E. A., and Old, L. J., Lancet, ii, 1207–1209 (1974).
Lilly, F., Genetics, 53, 529–539 (1966).
Sato, H., Boyse, E. A., Aoki, T., Iritani, C., and Old, L. J., J. exp. Med., 138, 593–606 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOMARD, E., LECLERC, J. & LEVY, J. Spontaneous antilymphoma reaction of preleukaemic AKR mice is a non-T-cell killing. Nature 250, 671–673 (1974). https://doi.org/10.1038/250671a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/250671a0
This article is cited by
-
In vivo and in vitro properties of malignant variants of RAW117 metastatic murine lymphoma/lymphosarcoma
Clinical & Experimental Metastasis (1983)
-
T-cell mediated immunity towards antigen(s) on isologous erythrocytes
Nature (1977)
-
Non-adaptive rejection of small tumour inocula as a model of immune surveillance
Nature (1976)
-
The genetic control of natural killer cell activity and its association with in vivo resistance against a moloney lymphoma isograft
Immunogenetics (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.