Abstract
THE study of the genetic control of immunoglobulin synthesis has been greatly hampered by the difficulty of detecting individual genes encoding variable regions (V genes). The distinction by allotypy of several V-gene loci in the rabbit is useful, but genetic studies on this species have obvious disadvantages. The discovery in inbred mice of crossreactive idiotypes1,2 and of their polymorphic expression3–6 allows a new approach to the genetic analysis of mouse immunoglobulins. The results presented here suggest that idiotypes may serve to distinguish individual V-gene loci within the mouse heavy chain linkage group and to detect recombinations between them.
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EICHMANN, K., TUNG, A. & NISONOFF, A. Linkage and rearrangement of genes encoding mouse immunoglobulin heavy chains. Nature 250, 509–511 (1974). https://doi.org/10.1038/250509a0
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DOI: https://doi.org/10.1038/250509a0
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