Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Defective DNA repair in Fanconi's anaemia

Abstract

FIBROBLASTS from patients with Fanconi's anaemia (FA) show increased susceptibility to transformation in vitro by SV40 virus1, as well as spontaneous chromosome breakage2. Chromosomal instability has also been observed in cultured peripheral blood lymphocytes and in bone marrow cells3. More recently, Sasaki and Tonomura4 demonstrated an increased susceptibility of lymphocytes from patients with FA to chromosome breakage by DNA cross linking agents. These results were interpreted as an indication that FA cells are defective in some DNA repair mechanism.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Todaro, G. J., Green, H., and Swift, M. R., Science, 153, 1252–1254 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Schroeder, R. M., Anschütz, F., and Knopp, A., Humangenetik, 1, 194–196 (1964).

    CAS  PubMed  Google Scholar 

  3. Swift, M. R., and Hirschhorn, K., Ann. intern. Med., 65, 496–503 (1966).

    Article  CAS  Google Scholar 

  4. Sasaki, M. S., and Tonomura, A., Cancer Res., 33, 1829–1836 (1973).

    CAS  Google Scholar 

  5. Cleaver, J. E., J. invest. Dermat., 54, 181–195 (1970).

    Article  CAS  Google Scholar 

  6. Cleaver, J. E., Nature, 218, 652–656 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Jacobs, A. J., O'Brien, R. L., Parker, J. W., and Paolilli, P., Mutat. Res., 16, 420–424 (1972).

    Article  CAS  Google Scholar 

  8. Stich, H. F., and San, R. H. C., Mutat. Res., 13, 279–282 (1971).

    Article  CAS  Google Scholar 

  9. Lindahl, T., Gally, J. A., and Edelman, G. M., Proc. natn. Acad. Sci. U.S.A., 62, 597–603 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Regan, J. D., Setlow, R. B., Carrier, W. L., and Lee, W. H., in Proc. fourth int. Cong. Radial. Res., Symp. Biol. Med. North Holland, Amsterdam, (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

POON, P., O'BRIEN, R. & PARKER, J. Defective DNA repair in Fanconi's anaemia. Nature 250, 223–225 (1974). https://doi.org/10.1038/250223a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/250223a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing