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Altered metabolism of carcinoembryonic antigen in hamsters bearing GW-39 tumours

Nature volume 249, pages 837–838 (1974)Cite this article

Abstract

THE liver is well known for its role in the catabolism of a variety of plasma glycoproteins1. Liver-mediated clearance of a tumour glycoprotein antigen, the carcinoembryonic antigen (CEA) associated with human gastrointestinal adenocarcinomas2, has been demonstrated in dogs and rabbits3. Since circulating CEA is being extensively investigated for its diagnostic value in the detection of cancer patients, we were prompted to determine the metabolism of CEA in a xenogeneic species which supports the growth of a CEA-producing colonic cancer.

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Authors and Affiliations

  1. Department of Immunology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110

    F. JAMES PRIMUS & HANS J. HANSEN

  2. Department of Pathology, University of Kentucky Medical Center, Lexington, Kentucky, 40506

    DAVID M. GOLDENBERG

Authors
  1. F. JAMES PRIMUS
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  2. HANS J. HANSEN
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  3. DAVID M. GOLDENBERG
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PRIMUS, F., HANSEN, H. & GOLDENBERG, D. Altered metabolism of carcinoembryonic antigen in hamsters bearing GW-39 tumours. Nature 249, 837–838 (1974). https://doi.org/10.1038/249837a0

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  • DOI: https://doi.org/10.1038/249837a0

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