Abstract
THERE is considerable evidence of neuromuscular dysfunction in most patients with all types of the functional psychoses. Examples of such dysfunction are (1) increased activity of skeletal-muscle-type creatine phosphokinase (CPK) in serum in the acute stage of psychosis1–4; (2) abnormally large increases in serum CPK activity with a standardised exercise test performed by patients in symptomatic remission5; (3) morphological abnormalities in skeletal muscle fibres at biopsy, particularly scattered atrophic fibres and extensive areas of Z-band streaming6–8; and (4) abnormalities of eye movements in tracking a pendulum9. The skeletal muscle fibre abnormalities found in psychotic patients are likely to be neurogenic in origin10.
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MELTZER, H., CRAYTON, J. Subterminal motor nerve abnormalities in psychotic patients. Nature 249, 373–375 (1974). https://doi.org/10.1038/249373a0
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DOI: https://doi.org/10.1038/249373a0
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