Abstract
HARRIS et al.1 have shown that hybrid cells (A9/SEWA) derived from fusion of cells of polyoma-induced sarcoma (SEWA) and an aneuploid long-established fibroblast line (of L origin), A9, had low tumorigenicity (Table 1)2. They have also shown3 that the polyoma-induced transplantation antigen (PTA) was present in low tumorigenic hybrids of SEWA/T6 T6. To investigate the relationship between malignancy and cell surface modifications, we analysed, in this system, the polyoma-specific surface antigen revealed by immunofluorescence4 concurrently with other characteristics of these cells, such as karyotype, transplantability and the presence of T antigen.
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MEYER, G., BEREBBI, M. & KLEIN, G. Expression of polyoma-induced antigens in low malignant hybrids derived from fusion of a polyoma-induced tumour with a fibroblast line. Nature 249, 47–49 (1974). https://doi.org/10.1038/249047a0
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DOI: https://doi.org/10.1038/249047a0
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