Abstract
MAREK'S disease (MD) is a lymphoproliferative disease of chickens which is generally considered to be neoplastic1. It is probably the most commonly occurring neoplasm of any animal and until recently it caused extensive economic loss, estimated to be in excess of 150 million dollars annually, to the poultry industry2. Several viral vaccines which will effectively prevent the disease have been developed3 and the most extensively used is a herpesvirus isolated from turkeys (HVT)4, which will prevent the disease in laboratory and field trials5,6.
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References
Payne, L. N., in Oncogenesis and Herpesviruses (edit. by Biggs, P. M., de-The, G., and Payne, L. N.), 2, 21 (Lyon, France, 1972).
Witter, R. L., in Oncogenesis and Herpesviruses (edit. by Biggs, P. M., de-The, G., and Payne, L. N.), 2, 21 (Lyon France, 1972).
Purchase, H. G., Witter, R. L., Okazaki, W., and Burmester, B. R., Perspect. Virol., 7, 91 (1971).
Witter, R. L., Nazerian, K., Purchase, H. G., and Burgoyne, G. H., Am. J. vet. Res., 31, 525 (1970).
Okazaki, W., Purchase, H. G., and Burmester, B. R., Avian Dis., 14, 413 (1970).
Purchase, H. G., Okazaki, W., and Burmester, B. R., Avian Dis., 16, 34 (1972).
Purchase, H. G., and Okazaki, W., Avian Dis., 15, 391 (1971).
Eidson, C. S., Fletcher, O. J., Kleven, S. H., and Anderson, D. P., J. natn. Cancer Inst., 47, 113 (1971).
Biggs, P. M., Jackson, C. A. W., Bell, R. A., Lancaster, F. M., and Milne, B. S., in Oncogenesis and Herpesviruses (edit. by Biggs P. M., de-The, G., and Payne, L. N.), 2, 139 (Lyon, France, 1972).
Hilleman, M. R., Perspect. Virol., 8, 119 (1973).
Klein, G., in Oncogenesis and Herpesviruses (edit. by Biggs, P. M., de-The, G., and Payne, L. N.), 2, 501 (Lyon, France, 1972).
Rouse, B. T., Wells, R. J. H., and Warner, N. L., J. Immun., 110, 534 (1973).
Hudson, L., and Payne, L. N., Nature new Biol., 241, 52 (1973).
Payne, L. N., and Rennie, M., J. natn. Cancer Inst., 45, 387 (1970).
Crittenden, L. B., Wld's Poult. Sci. J., 24, 18 (1968).
Witter, R. L., Solomon, J. J., and Burgoyne, G. H., Avian Dis., 13, 101 (1969).
Okazaki, W., Purchase, H. G., and Noll, L., Avian Dis., 14, 532 (1970).
Purchase, H. G., and Burgoyne, G. H., Am. J. vet. Res., 31, 117 (1970).
Wegmann, T. G., and Smithies, O., Transfusion, 6, 67 (1966).
Payne, L. N., and Biggs, P. M., J. natn. Cancer Inst., 39, 281 (1967).
Purchase, H. G., Burmester, B. R., and Cunningham, C. H., Infec. Immun., 3, 295 (1971).
Purchase, H. G., and Biggs, P. M., Res. vet. Sci., 8, 440 (1967).
Linna, T. J., Frommel, D., and Good, R. A., Int. Arch. Allergy, 42, 20 (1972).
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PURCHASE, H., SHARMA, J. Amelioration of Marek's disease and absence of vaccine protection in immunologically deficient chickens. Nature 248, 419–421 (1974). https://doi.org/10.1038/248419a0
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DOI: https://doi.org/10.1038/248419a0
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