Abstract
IT is well established that the kidney is the main site of the production and/or activation of erythropoietin (Ep)1,2. Gordon et al.3 have presented evidence indicating that under both normal and hypoxic conditions the production of circulating Ep involves the interaction of a renal erythropoietic factor (also termed erythrogenin) with a serum protein component. Erythrogenin can be extracted from the light mitochondrial fraction prepared from homogenates of mammalian kidneys.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jacobson, L. O., Goldwasser, E., Fried, W., and Plzak, L., Nature, 179, 633 (1957).
Naets, J. P., J. Clin. Invest., 39, 102 (1960).
Gordon, A. S., Cooper, G. W., and Zanjani, E. D., Sent. Hem., 4, 337 (1967).
Naets, J. P., and Wittek, M., Blood, 31, 249 (1968).
Fried, W., Kilbridge, T., Krantz, S. B., McDonald, T. P., and Lange, R. D., J. Lab. Clin. Med., 73, 244 (1969).
Peschle, C., Sasso, G. F., Rappaport, I. A., and Condorelli, M., J. Lab. Clin. Med., 79, 950 (1972).
Schooley, J. C., and Mahlmann, L. J., Blood, 39, 31 (1972).
Peschle, C., Rappaport, I. A., Sasso, G. F., Chiariello, M., Condorelli, M., and Gordon, A. S., in Proc. Fifteenth Amer. Soc. Hemat. (Hollywood, 1972).
Fried, W., Blood, 40, 671 (1972).
Peschle, C., Sasso, G. F., Rappaport, I. A., Rossanigo, F., Gordon, A. S., and Condorelli, M., Proc. First Intern. Conf. Hematopoiesis. Regulation of Erythropoiesis (edit. by Gordon, A. S., Condorelli, M., and Peschle, C.) (Il Ponte, Milan, 1972).
Cantor, L. N., Zanjani, E. D., Wong, K. K., and Gordon, A. S., Proc. Soc. Exp. Biol. Med., 130, 950 (1969).
Gordon, A. S., Zanjani, E. D., and Zaluski, R., Blood, 35, 151 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PESCHLE, C., D'AVANZO, A., RAPPAPORT, I. et al. Role of Erythrogenin from Liver and Spleen in Erythropoietin Production in the Anephric Rat. Nature 243, 539–541 (1973). https://doi.org/10.1038/243539b0
Received:
Issue Date:
DOI: https://doi.org/10.1038/243539b0
This article is cited by
-
Effect of hypoxemia on erythropoietic activity of organs during perfusion
Bulletin of Experimental Biology and Medicine (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
