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Transformation of Mammalian Cells in vitro by Low Doses of X-rays

A Corrigendum to this article was published on 21 September 1973

Abstract

X-irradiation of hamster embryo cells in culture, followed by cloning of the cells, was used to obtain a dose–response curve in terms of cell transformation. Transformations were observed for doses as low as 1 rad.

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References

  1. Borek, C., and Sachs, L., Nature, 210, 276 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Borek, C., Higashino, S., and Loewenstein, W. R., J. Memb. Biol., 1, 274 (1969).

    Article  CAS  Google Scholar 

  3. Borek, C., and Sachs, L., Proc. US Nat. Acad. Sci., 57, 1522 (1967).

    Article  ADS  CAS  Google Scholar 

  4. Borek, C., and Sachs, L., Proc. US Nat. Acad. Sci., 59, 83 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Borek, C., and Sachs, L., Proc. US Nat. Acad. Sci., 56, 1705 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Inbar, M., and Sachs, L., Proc. US Nat. Acad. Sci., 63, 1418 (1969).

    Article  ADS  CAS  Google Scholar 

  7. Klein, J. C., van der Western, A. M., and Hasper, J., Ann. Rep. Radiobiol. Inst., 53 (TNO, Rijswijk, 1970).

  8. Borek, C., Proc. US Nat. Acad. Sci., 69, 956 (1972).

    Article  ADS  CAS  Google Scholar 

  9. Ham, R. G., and Puck, T. T., Methods in Enzymol. (edit. by Colwick, S. P., and Kaplan, M. D.), 5, 90 (1952).

    Google Scholar 

  10. Sanders, F. K., and Burford, B. O., Nature, 200, 786 (1964).

    Article  ADS  Google Scholar 

  11. MacPherson, I., and Montagnier, L., Virology, 23, 291 (1964).

    Article  CAS  Google Scholar 

  12. Burger, M. M., Proc. US Nat. Acad. Sci., 62, 994 (1969).

    Article  ADS  CAS  Google Scholar 

  13. Borek, C., Grob, M., and Burger, M. M., Exp. Cell. Res., 77, 107 (1973).

    Article  Google Scholar 

  14. Whitmore, G. F., and Till, J. E., Ann. Rev. Nuclear Sci., 14, 347 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 52 (1962).

    Google Scholar 

  16. Miller, D. A., Dev, V. G., Borek, C., and Miller, O. J., Cancer Res., 32, 2374 (1972).

    Google Scholar 

  17. Weinstein, I. B., Gerbert, R., Stadler, U. C., Orenstein, J. M., and Axel, R., Science, 178, 1098 (1972).

    Article  ADS  CAS  Google Scholar 

  18. Furth, J., and Lorenz, E., Radiation Biology (edit. by Hollander, A. H.), 1, 1145 (1954).

    Google Scholar 

  19. Bond, V. P., Cronkite, E. P., Lippincott, S. W., and Shellabarger, C. J., Rad. Res., 12, 276 (1960).

    Article  CAS  Google Scholar 

  20. Upton, A. C., Cancer Res., 21, 717 (1961).

    CAS  PubMed  Google Scholar 

  21. Gray, L. H., Cellular Radiation Biology, 7 (William and Wilkins, Baltimore, 1965).

    Google Scholar 

  22. International Commission on Radiological Protection Publication No. 9 (Pergamon, New York, 1966).

  23. Health Physics, 12, 302 (1966).

  24. Rossi, H. H., and Kellerer, A. M., Science, 175, 200 (1972).

    Article  ADS  CAS  Google Scholar 

  25. Puck, T. T., Rev. Mod. Phys., 31, 433 (1959).

    Article  ADS  CAS  Google Scholar 

  26. Puck, T. T., Proc. US Nat. Acad. Sci., 44, 772 (1958).

    Article  ADS  CAS  Google Scholar 

  27. Yamada, M., and Puck, T. T., Proc. US Nat. Acad. Sci., 47, 1181 (1961).

    Article  ADS  CAS  Google Scholar 

  28. Stoker, M. G. P., Proc. Roy. Soc., B, 181, 1 (1972).

    ADS  CAS  Google Scholar 

  29. Liaharman, M., and Kaplan, H. L., Science, 130, 387 (1959).

    Article  ADS  Google Scholar 

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BOREK, C., HALL, E. Transformation of Mammalian Cells in vitro by Low Doses of X-rays. Nature 243, 450–453 (1973). https://doi.org/10.1038/243450a0

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