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Lymphoma

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Leukemia volume 22, pages 400–405 (2008)Cite this article

Abstract

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.

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Acknowledgements

The expert technical assistance of Elena Fischer, Irmgard Henke, and Reina Zühlke-Jenisch is gratefully acknowledged. This study was supported by the Deutsche Krebshilfe/Dr Mildred Scheel Stiftung für Krebsforschung (Grant no. 10-2153-De 1).

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Authors and Affiliations

  1. Department of Neuropathology, University Hospital of Cologne, Cologne, Germany

    M Montesinos-Rongen, A Brunn & M Deckert

  2. Institute for Cancer Genetics, Columbia University, New York, NY, USA

    M Montesinos-Rongen, K Basso, W K Lim & R Dalla-Favera

  3. Institute for Functional Genomics, University of Regensburg, Regensburg, Germany

    S Bentink & R Spang

  4. Institute of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    W Klapper

  5. Department of Neurosurgery, University Hospital Bonn, Bonn, Germany

    C Schaller

  6. Department of Neuropathology, Heinrich Heine University, D, ü, sseldorf, Germany

    G Reifenberger

  7. Division of Hematology/Oncology, University of California, San Francisco, CA, USA

    J Rubenstein

  8. German Cancer Research Center, Heidelberg, Germany

    O D Wiestler

  9. Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Germany

    R Siebert

Authors
  1. M Montesinos-Rongen
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  5. W K Lim
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  7. C Schaller
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  8. G Reifenberger
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  9. J Rubenstein
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  10. O D Wiestler
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  11. R Spang
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  12. R Dalla-Favera
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  13. R Siebert
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  14. M Deckert
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Corresponding author

Correspondence to M Deckert.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Montesinos-Rongen, M., Brunn, A., Bentink, S. et al. Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. Leukemia 22, 400–405 (2008). https://doi.org/10.1038/sj.leu.2405019

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  • DOI: https://doi.org/10.1038/sj.leu.2405019

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