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Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors

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References

  1. Royer-Pokora B, Loos U, Ludwig WD . TTG-2 a new gene encoding a cysteine-rich protein with LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 1991; 6: 1887–1893.

    CAS  PubMed  Google Scholar 

  2. Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R, Rabbitts TH . The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci USA 1998; 95: 3890–3895.

    Article  CAS  Google Scholar 

  3. Yamada Y, Pannell R, Forster A, Rabbitts TH . The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci USA 2000; 97: 320–324.

    Article  CAS  Google Scholar 

  4. Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997; 16: 3145–3157.

    Article  CAS  Google Scholar 

  5. Shivdasani RA . MicroRNAs: regulators of gene expression and cell differentiation. Blood 2006; 108: 3646–3653.

    Article  CAS  Google Scholar 

  6. Fazi F, Rosa A, Fatica A, Gelmetti V, Marchis MLD, Nervi C et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123: 819–831.

    Article  CAS  Google Scholar 

  7. Fukao T, Fukuda Y, Kiga K, Sharif J, Hino K, Enomoto Y et al. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 2007; 129: 617–631.

    Article  CAS  Google Scholar 

  8. Nam CH, Rabbitts TH . The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. Mol Ther 2006; 13: 15–25.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Nature Science Foundation of China (No.30771054).

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Correspondence to T-H Zhu.

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Yuan, W., Sun, W., Yang, S. et al. Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. Leukemia 22, 1067–1071 (2008). https://doi.org/10.1038/sj.leu.2405001

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