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Conventional cytogenetics of nodular lymphocyte-predominant Hodgkin's lymphoma

Leukemia volume 21, pages 2064–2067 (2007)Cite this article

The World Health Organization classification of the tumors of hematopoietic and lymphoid tissues distinguishes nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) from classical Hodgkin's lymphoma (CHL) on morphological, clinical and biological differences.1 NLPHL accounts for approximately 5% of all Hodgkin's lymphomas and usually presents as an early stage disease, with slow progression and a favorable outcome.2 Response to conventional therapy, when indicated, is excellent. Transformation to diffuse large B-cell lymphoma has been reported in approximately 3–5% of cases. Tumor cells, known as ‘popcorn’ or L&H cells, express B-cell antigens like CD20 and CD45, usually do not express CD15 and CD30 and probably are of centroblastic origin. Cytogenetic characteristics of NLPHL have been rarely reported, and were mainly obtained using molecular cytogenetic methods like fluorescent in situ hybridization (FISH) or comparative genomic hybridization (CGH).3, 4

Between 1979 and 2004, 22 patients referred to the Centre Henri Becquerel had a diagnosis of NLPHL. A single lymph node biopsy was used for morphologic, immunologic, molecular and cytogenetic studies, including molecular cytogenetics. After an expert review, patients suspected to have atypical diffuse large B-cell lymphoma or a CHL were excluded and 13 patients with an ascertained NLPHL diagnosis were retained and are reported here. Clinical and pathological characteristics are summarized in Table 1. Median age was 32 years (range 6–57). All patients had localized peripheral lymphadenopathy (stage I: 7 or stage II: 6). None had extra-nodal involvement or B symptoms. Five were treated at diagnosis or later, and eight patients did not receive any treatment and remained in stable disease. Median follow-up for this series is 59.8 months.

Table 1 Clinical data, histology and immunohistology
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Authors and Affiliations

  1. Groupe d'étude des proliférations lymphoïdes, Centre Henri Becquerel, Rouen, France

    A Stamatoullas, J-M Picquenot, P Ruminy, D Penther, P Bertrand, M-N Courel, C Maisonneuve, H Tilly & C Bastard

  2. Service d'Hématologie Pédiatrique, CHU Rouen, France

    C Dumesnil

  3. Département d'Anatomo-Pathologie, CHU Rouen, France

    A François

  4. Département d'Anatomo-Pathologie, Hôpital Henri Mondor, Créteil, France

    P Gaulard

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  1. A Stamatoullas
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Correspondence to A Stamatoullas.

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Stamatoullas, A., Picquenot, JM., Dumesnil, C. et al. Conventional cytogenetics of nodular lymphocyte-predominant Hodgkin's lymphoma. Leukemia 21, 2064–2067 (2007). https://doi.org/10.1038/sj.leu.2404736

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