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The JAK2 V617F mutation is detectable in granulocyte populations at greater than two copies per cell among individuals with myeloproliferative disorders

Leukemia volume 21, pages 815–816 (2007)Cite this article

A recent letter in Leukemia1 reported the detection of the JAK2 V617F mutation at very low levels in peripheral blood of healthy donors. This finding is consistent with our own data generated using TaqMan (fluorescence-based real-time PCR) and minor groove binding probes designed for the quantitative determination of DNA copy number of JAK2 V617F.2

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References

  1. Sidon P, EL Housni H, Dessars B, Heimann L . The JAK2 V617F mutation is detectable at very low level in peripheral blood of healthy donors. Leukemia 2006 [E-pub ahead of print] doi:10.1038/sj.leu.2404292.

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  2. Hammond E, Shaw K, Carnley B, P'ng S, James I, Herrmann R . Quantitative determination of JAK2 V617F by TaqMan: an absolute measure of averaged copies per cell that may be associated with the different types of myeloproliferative disorders. J Mol Diagnostics (in press).

  3. Hammond EL, Sayer D, Nolan D, Walker U, deRonde A, Montaner J et al. Assessment of precision and concordance of quantitative mitochondrial DNA assays: a collaborative international quality assurance study. J Clin Virol 2003; 27: 97–110.

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Authors and Affiliations

  1. Centre for Clinical Immunology and Biomedical Statistics, Murdoch University, Western Australia, Australia

    E Hammond

  2. Cellular and Tissue Therapies, Royal Perth Hospital, Western Australia, Australia

    K Shaw

  3. Department of Haematology, Pathwest, Royal Perth Hospital, Western Australia, Australia

    R Herrmann

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  1. E Hammond
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  2. K Shaw
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  3. R Herrmann
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Correspondence to E Hammond.

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Hammond, E., Shaw, K. & Herrmann, R. The JAK2 V617F mutation is detectable in granulocyte populations at greater than two copies per cell among individuals with myeloproliferative disorders. Leukemia 21, 815–816 (2007). https://doi.org/10.1038/sj.leu.2404567

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