This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Temozolomide and cisplatin in relapsed/refractory acute leukemia
Journal of Hematology & Oncology Open Access 22 May 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Goldstone AH, Burnett AK, Wheatley K, Smith AG, Hutchinson M, Clark RE . Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98: 1302–1311.
Grimwade D, Walker H, Harrison G, Oliver F, Chatters S, Harrison CJ et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98: 1312–1320.
Gupta V, Chun K, Yi Q-L, Minden M, Schuh A, Wells R et al. Disease biology rather than age is the most important determinant of survival of AML patients ⩾60 years treated with uniform intensive therapy. Cancer 2005; 103: 2082–2090.
Leopold LH, Willemze R . The treatment of acute myeloid leukemia in first relapse: a comprehensive review of the literature. Leuk Lymph 2002; 43: 1715–1727.
Seiter K, Liu D, Loughran T, Siddiqui A, Baskind P, Ahmed T . Phase I study of temozolomide in relapsed/refractory acute leukemia. J Clin Oncol 2002; 20: 3249–3253.
Graziani G, Faraoni I, Grohmann U, Bianchi R, Binaglia L, Margison GP et al. O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Cancer Res 1995; 55: 6231–6236.
Hegi ME, Diserens A-C, Gorlia T, Hamou M-F, de Tribolet N, Weller M et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352: 997–1003.
D’Atri S, Piccioni D, Castellano A, Tuorto V, Franchi A, Lu K et al. Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukemia patients. Ann Oncol 1995; 6: 389–393.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Brandwein, J., Yang, L., Schimmer, A. et al. A phase II study of temozolomide therapy for poor-risk patients aged ⩾60 years with acute myeloid leukemia: low levels of MGMT predict for response. Leukemia 21, 821–824 (2007). https://doi.org/10.1038/sj.leu.2404545
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2404545
This article is cited by
-
Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells
Medical Oncology (2012)
-
Temozolomide and cisplatin in relapsed/refractory acute leukemia
Journal of Hematology & Oncology (2009)