This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
Cell Death Discovery Open Access 27 July 2023
-
Clinical Indicators of Hepatotoxicity in Newly Diagnosed Acute Promyelocytic Leukemia Patients Undergoing Arsenic Trioxide Treatment
Biological Trace Element Research Open Access 25 April 2023
-
Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model
Journal of Experimental & Clinical Cancer Research Open Access 23 June 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Douer D, Tallman MS . Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies. J Clin Oncol 2005; 23: 2396–2410.
Vahter M . Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity. Toxicol Lett 2000; 112–113: 209–217.
Brouwer OF, Onkenhout W, Edelbroek PM, de Kom JF, de Wolff FA, Peters AC . Increased neurotoxicity of arsenic in MTHFR deficiency. Clin Neurol Neurosurg 1992; 94: 307–310.
Chiou HY, Hsueh YM, Hsieh LL, Hsu LI, Hsu YH, Hsieh FI et al. Arsenic methylation capacity, body retention and null genotypes of glutathione S-transferases M1 and T1 among current arsenic exposed residents of Taiwan. Mutat Res 1997; 386: 197–207.
Coles BF, Morel F, Rauch C, Huber WW, Yang M, Teitel CH et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001; 11: 663–669.
Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 1999; 96: 12810–12815.
Arand M, Muhlbauer R, Hengstler J, Jager E, Fuchs J, Winkler L et al. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 1996; 236: 184–186.
Mathews V, George B, Lakshmi KM, Viswabandya A, Bajel A, Balasubramaniam P et al. Single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood 2005, Dec 13 (E-pub ahead of print).
Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell Jr RP . The ‘retinoic acid syndrome’ in acute promyelocytic leukemia. Ann Intern Med 1992; 117: 292–296.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mathews, V., Desire, S., George, B. et al. Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity. Leukemia 20, 881–883 (2006). https://doi.org/10.1038/sj.leu.2404165
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2404165
This article is cited by
-
Clinical Indicators of Hepatotoxicity in Newly Diagnosed Acute Promyelocytic Leukemia Patients Undergoing Arsenic Trioxide Treatment
Biological Trace Element Research (2024)
-
An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
Cell Death Discovery (2023)
-
Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3
Archives of Toxicology (2020)
-
Clinical pharmacokinetics and safety profile of single agent arsenic trioxide by continuous slow-rate infusion in patients with newly diagnosed acute promyelocytic leukemia
Cancer Chemotherapy and Pharmacology (2018)
-
Morphine Attenuated the Cytotoxicity Induced by Arsenic Trioxide in H9c2 Cardiomyocytes
Biological Trace Element Research (2016)