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Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia

Leukemia volume 19, pages 2339–2341 (2005)Cite this article

TO THE EDITOR

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the Western world. In spite of recent immunophenotypic, cytogenetic and molecular advances in the characterization of CLL, the oncogenic and cellular pathways are still poorly understood. A monoclonal B-cell lymphocytosis (MBL) could represent, in a proportion of cases, an early stage of CLL,1, 2, 3 and an increased prevalence of MBL in first-degree relatives (FDR) of familial CLL compared to the general population has been reported.4, 5 In order to study MBL as the early precursor of CLL, we investigated peripheral blood from the unaffected FDR of familial CLL, using high-sensitivity, multicolor flow cytometry (MCFCM) techniques, that is, seven-color, nine parameters.

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Authors and Affiliations

  1. Institut Paoli-Calmettes, Marseille, France

    T Aurran-Schleinitz

  2. Flow Cytometry Core Facility, ETIB, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    W Telford

  3. Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA

    S Perfetto

  4. Genetics Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    N Caporaso

  5. MOCRU, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    W Wilson

  6. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    M A Stetler-Stevenson

  7. Division of Cell and Gene Therapies, Office of Cellular, Tissues and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA

    T Aurran-Schleinitz, V E Zenger, F Abbasi & G E Marti

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  1. T Aurran-Schleinitz
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  2. W Telford
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  3. S Perfetto
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  4. N Caporaso
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  5. W Wilson
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  6. M A Stetler-Stevenson
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  7. V E Zenger
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  8. F Abbasi
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  9. G E Marti
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Correspondence to G E Marti.

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Aurran-Schleinitz, T., Telford, W., Perfetto, S. et al. Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia. Leukemia 19, 2339–2341 (2005). https://doi.org/10.1038/sj.leu.2403980

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  • DOI: https://doi.org/10.1038/sj.leu.2403980

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