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The MIF-173G/C polymorphism does not contribute to prednisone poor response in vivo in childhood acute lymphoblastic leukemia

Leukemia volume 19, pages 2346–2347 (2005)Cite this article

TO THE EDITOR

Treatment results of childhood acute lymphoblastic leukemia (ALL) have greatly improved over the last decades. Identification of patients at higher risk of treatment failure remains one major target of current clinical research in this field. In the last decade the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP)1 and the Berlin–Frankfurt–Münster (BFM) study groups have emphasized the role of corticosteroid sensitivity of leukemic blasts at the time of diagnosis, a risk feature first described and subsequently assessed by the BFM group.2 Patients with ⩾1000 blast cells per μl of peripheral blood after 7 days of prednisone monotherapy and one injection of intrathecal methotrexate (IT-MTX) were considered to have a poor response to prednisone (PPR) and no more than a 35% chance of becoming long-term disease-free survivors on standard therapeutic protocols.3 Recently their outcome has improved when more intensive chemotherapy has been applied.4

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Authors and Affiliations

  1. Onco-Ematologia Pediatrica, Ospedale dei Bambini ‘G. Di Cristina’, Palermo, Italy

    O Ziino & M Aricò

  2. Laboratorio di Reumatologia, Direzione Scientifica, IRCCS Ospedale Pediatrico Bambino Gesù, Italy

    L E D'Urbano & F De Benedetti

  3. Clinica Pediatrica, Università Milano-Bicocca, Ospedale San Gerardo, Monza, Italy

    V Conter

  4. Oncoematologia Pediatrica Ospedale Infantile Regina Margherita, Torino, Italy

    E Barisone

  5. Ematologia Pediatrica, IRCCS Bambin Gesù, Roma, Italy

    G De Rossi

  6. Onco-Ematologia Pediatrica, Università di Padova, Italy

    G Basso

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  1. O Ziino
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  8. M Aricò
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for the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)

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Correspondence to M Aricò.

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Ziino, O., D'Urbano, L., De Benedetti, F. et al. The MIF-173G/C polymorphism does not contribute to prednisone poor response in vivo in childhood acute lymphoblastic leukemia. Leukemia 19, 2346–2347 (2005). https://doi.org/10.1038/sj.leu.2403973

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  • DOI: https://doi.org/10.1038/sj.leu.2403973

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