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A rare case of acute myeloid leukemia with a CHIC2-ETV6 fusiongen and multiple other molecular aberrations

Leukemia volume 19, pages 2366–2368 (2005)Cite this article

TO THE EDITOR

Acute myeloid leukemia (AML), like other human cancers, is the consequence of more than one mutation. Data from animal models of leukemia strongly support a multistep pathogenesis of the disease.1 Chromosomal translocations most frequently target transcription factors involved in the regulation of normal hematopoietic differentiation, whereas molecular mutations often affect genes involved in signal transduction pathways associated with cell proliferation. Here, we present a case with multiple genetic and molecular defects targeting transcription factors as well as tyrosine kinases in a rare constellation.

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Authors and Affiliations

  1. Department of Medicine III, Laboratory for Leukemia Diagnostics, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany

    F Kuchenbauer & C Schoch

  2. Department of Hematology/Oncology, Klinikum Regensburg, University of Regensburg, Regensburg, Germany

    E Holler

  3. Department of Medicine III, Laboratory for Leukemia Diagnostics, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany

    T Haferlach, W Hiddemann & S Schnittger

Authors
  1. F Kuchenbauer
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  2. C Schoch
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  3. E Holler
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  4. T Haferlach
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  5. W Hiddemann
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  6. S Schnittger
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Correspondence to F Kuchenbauer.

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Kuchenbauer, F., Schoch, C., Holler, E. et al. A rare case of acute myeloid leukemia with a CHIC2-ETV6 fusiongen and multiple other molecular aberrations. Leukemia 19, 2366–2368 (2005). https://doi.org/10.1038/sj.leu.2403957

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