Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression

Leukemia volume 19, pages 1708–1709 (2005)Cite this article

TO THE EDITOR

The adhesion and migration properties of a cell and its interaction with stroma or other cells are modulated, among others, by tetraspanin proteins.1 Tetraspanin antigens are a family of 28 membrane proteins widely expressed in different cell types. Each cell type displays a specific pattern of expression of several tetraspanins that interact among themselves forming a tetraspanin complex. This complex forms a new type of membrane microdomain1, 2 that interacts with other membrane proteins, such as integrins, CD19, CD21, HLA-class II antigens and some growth factor receptors.2 The specific function of the tetraspanin proteins is not well understood, but they clearly modulate the biological function of the associated molecules in the complex.3 Therefore, the pattern of expression of tetraspanin and tetraspanin-associated molecules can modulate the adhesion and migration characteristics of both normal and tumor cells. In the hematopoietic system, B-cell maturation is associated with changes in the pattern of expression of tetraspanins.4 Also in, B-cell malignancies, the tetraspanin phenotype appears to reflect the differentiation stage of the cell of origin, and thus can be of use in tumor phenotyping.4

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Hemler ME . Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol 2003; 19: 397–422.

    Article  CAS  Google Scholar 

  2. Yunta M, Lazo PA . Tetraspanin proteins as organisers of membrane microdomains and signalling complexes. Cell Signal 2003; 15: 559–564.

    Article  CAS  Google Scholar 

  3. Yunta M, Lazo PA . Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene 2003; 22: 1219–1224.

    Article  CAS  Google Scholar 

  4. Barrena S, Almeida J, Yunta M, López A, Fernández-Mosteirín N, Giralt M et al. Aberrant expression of tetraspanin molecules in B-cell neoplasias and its correlation with normal B-cell maturation. Leukemia 2005; 19: in press.

  5. Sanchez ML, Almeida J, Gonzalez D, Gonzalez M, Garcia-Marcos MA, Balanzategui A et al. Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone. Blood 2003; 102: 2994–3002.

    Article  CAS  Google Scholar 

  6. Cherukuri A, Shoham T, Sohn HW, Levy S, Brooks S, Carter R et al. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol 2004; 172: 370–380.

    Article  CAS  Google Scholar 

  7. Tedder TF, Inaoki M, Sato S . The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 1997; 6: 107–118.

    Article  CAS  Google Scholar 

  8. Sanchez ML, Almeida J, Vidriales B, Lopez-Berges MC, Garcia-Marcos MA, Moro MJ et al. Incidence of phenotypic aberrations in a series of 467 patients with B chronic lymphoproliferative disorders: basis for the design of specific four-color stainings to be used for minimal residual disease investigation. Leukemia 2002; 16: 1460–1469.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by Grants from MEC SAF2004-02900 (PAL) and SAF 2002-03096 (AO), Fondo de Investigación Sanitaria PI02-0585 (PAL), and Fundación Memoria Samuel Solórzano Barruso (PAL).

Author information

Authors and Affiliations

  1. Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain

    S Barrena, J Almeida, M Yunta, A López, J Díaz-Mediavilla, A Orfao & P A Lazo

  2. Servicio de Citometría, Universidad de Salamanca and Hospital Universitario de Salamanca, Salamanca, Spain

    S Barrena, J Almeida, A López & J Díaz-Mediavilla

Authors
  1. S Barrena
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Almeida
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Yunta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A López
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Díaz-Mediavilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A Orfao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P A Lazo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P A Lazo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barrena, S., Almeida, J., Yunta, M. et al. Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression. Leukemia 19, 1708–1709 (2005). https://doi.org/10.1038/sj.leu.2403858

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403858

This article is cited by

  • CD53

    • Monica Yunta
    • Pedro Lazo

    AfCS-Nature Molecule Pages (2009)

Search

Advanced search

Quick links