Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols

Leukemia volume 19, pages 1705–1708 (2005)Cite this article

TO THE EDITOR

T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of cases of childhood ALL. In earlier pediatric ALL clinical trials, the T-cell phenotype was associated with an unfavorable prognosis. However, the use of modern risk-adjusted multiagent treatment regimes has been reported to override this difference. While a 5-year event-free survival rate of approximately 70–75% is currently achieved in childhood T-ALL, a significant proportion of patients continue to relapse. Importantly, relapsed T-ALL confers an extremely poor prognosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Heerema NA, Sather HN, Sensel MG, Kraft P, Nachman JB, Steinherz PG et al. Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group. JCO 1998; 16: 1270–1278.

    Article  CAS  Google Scholar 

  2. Bernard OA, Busson-LeConiat M, Ballerini P, Mauchauffé M, Della Valle V, Monni R et al. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the HOX11L2 gene in T acute lymphoblastic leukemia. Leukemia 2001; 15: 1495–1504.

    Article  CAS  Google Scholar 

  3. Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH et al. Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukemia. Lancet 2004; 363: 535–536.

    Article  CAS  Google Scholar 

  4. Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002; 1: 75–87.

    Article  CAS  Google Scholar 

  5. Kees UR, Heerema NA, Kumar R, Watt PM, Baker DL, La MK et al. Expression of HOX11 in childhood T-lineage acute lymphoblastic leukemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG). Leukemia 2003; 17: 887–893.

    Article  CAS  Google Scholar 

  6. Ballerini P, Blaise A, Busson-Le Coniat M, Su XY, Zucman-Rossi J, Adam M et al. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. Blood 2002; 100: 991–997.

    Article  CAS  Google Scholar 

  7. Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A et al., for the EORTC-CLG. Clinical significance of HOX11L2 expression linked to t(5:14)(q35:q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. Blood 2004; 103: 442–450.

    Article  Google Scholar 

  8. Asnafi V, Beldjord K, Boulanger E, Comba B, Le Tutour P, Estienne M et al. Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 2003; 101: 2693–2703.

    Article  CAS  Google Scholar 

  9. Berger R, Dastugue N, Busson M, van den Akker J, Pérot C, Ballerini P, et al., on behalf of the Groupe Francais de Cytogénétique Hématologique (GFCH). t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogénétique Hématologique (GFCH). Leukemia 2003; 17: 1851–1857.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Childhood Cancer Foundation Laura and Greg Norman Fellowship (NGG), the Children's Leukemia and Cancer Research Foundation, Perth, Australia and National Institutes of Health Grant CA83088.

Author information

Authors and Affiliations

  1. Division of Children's Leukemia and Cancer Research and Center for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia

    N G Gottardo, P A Jacoby & U R Kees

  2. Department of Oncology & Hematology, Princess Margaret Hospital for Children, Perth, Australia

    N G Gottardo & D L Baker

  3. Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    H N Sather

  4. Department of Hematology-Oncology, Children's National Medical Center and George Washington University, Washington, DC, USA

    G H Reaman

Authors
  1. N G Gottardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P A Jacoby
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H N Sather
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G H Reaman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D L Baker
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. U R Kees
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N G Gottardo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gottardo, N., Jacoby, P., Sather, H. et al. Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. Leukemia 19, 1705–1708 (2005). https://doi.org/10.1038/sj.leu.2403834

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403834

This article is cited by

Search

Advanced search

Quick links