Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Expression of BEX1 in acute myeloid leukemia with MLL rearrangements

Leukemia volume 19, pages 1488–1489 (2005)Cite this article

TO THE EDITOR

For many years, cytomorphology and cytochemistry provided the basis for the classification of leukemias. More recently, immunophenotyping, cytogenetics and molecular genetics have contributed to tumor subclassification. Gene expression profiling promises to further improve tumor diagnosis. Determination of the expression of a limited number of genes may assist safe discrimination between tumor types. In recent years, it has been shown that not only acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), but also distinct subtypes of both diseases may be identified by the array technology.1, 2, 3

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286: 531–537.

    Article  CAS  Google Scholar 

  2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41–47.

    Article  CAS  Google Scholar 

  3. Schoch C, Kohlmann A, Schnittger S, Brors B, Dugas M, Mergenthaler S et al. Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci USA 2002; 99: 10008–10013.

    Article  CAS  Google Scholar 

  4. Quentmeier H, Dirks WG, MacLeod RAF, Reinhardt J, Zaborski M, Drexler HG . Expression of HOX genes in acute leukemia cell lines with and without MLL translocations. Leukemia Lymphoma 2004; 45: 567–574.

    Article  CAS  Google Scholar 

  5. Yang QS, Xia F, Gu SH, Yuan HL, Chen JZ, Yang QS et al. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. Biochem Genet 2002; 40: 1–12.

    Article  CAS  Google Scholar 

  6. Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem 2000; 275: 17566–17570.

    Article  CAS  Google Scholar 

  7. Behrens M, Margolis JW, Margolis FL . Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. J Neurochem 2003; 86: 1289–1296.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. H Quentmeier and R Tonelli: These two authors contributed equally

Authors and Affiliations

  1. Department of Human and Animal Cell Cultures, DSMZ - German Collection of Micoroorganisms and Cell Cultures, Braunschweig, Germany

    H Quentmeier, C C Uphoff & H G Drexler

  2. Department of Paediatrics, University of Bologna, Policlinico S. Orsola Malpighi, Bologna, Italy

    R Tonelli & A Pession

  3. Department of Mucosal Immunity, GBF - Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany

    R Geffers

Authors
  1. H Quentmeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Tonelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Geffers
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Pession
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C C Uphoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H G Drexler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H Quentmeier.

Additional information

Partially funded by: AIRC (Associazione Italiana Ricerca sul Cancro) regional grant 2004

Rights and permissions

Reprints and permissions

About this article

Cite this article

Quentmeier, H., Tonelli, R., Geffers, R. et al. Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. Leukemia 19, 1488–1489 (2005). https://doi.org/10.1038/sj.leu.2403820

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403820

This article is cited by

Search

Advanced search

Quick links