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Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma

Leukemia volume 19, pages 292–294 (2005)Cite this article

TO THE EDITOR

Mature B-cell neoplasms include B-cell chronic lymphocytic leukemia (B-CLL), follicular lymphoma (FL), mantle cell lymphoma (MCL) and splenic marginal zone B-cell lymphoma (SMZL), among others.1 These neoplasms have an increasing incidence in Western countries, where they account for about 75% of all lymphoid neoplasms. Therapeutic options for mature B-cell neoplasms include alkylating agents, purine nucleoside analogues, combination chemotherapy, interferon, and monoclonal antibodies. Although most patients respond to chemotherapy, these neoplasms are characterized by a continuous pattern of relapse and there is no standard treatment.2, 3, 4 Moreover, current chemotherapeutic agents are not selective for tumor cells and consequently they have several negative effects on the quality of life of those treated. For instance, purine analogues induce apoptosis of T cells, which leads to immunosuppression. Thus, new therapeutic drugs with a differential effect on B and T lymphocytes are of great interest.

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Acknowledgements

This study was supported by a grant from the Ministerio de Ciencia y Tecnología and FEDER (SAF 2001-3026) to J Gil and by Advanced In Vitro Cell Technologies, SL (Barcelona). We thank Dr José Manuel López, Dr Montserrat Barragán, Dr Esther Castaño, Dr Gabriel Pons, Dr Jordi Llorens, Daniel Iglesias and Llorenç Coll for helpful discussion and suggestions, and R Rycroft for language assistance. AF Santidrián is recipient of a research fellowship from the Ministerio de Educación y Ciencia.

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Authors and Affiliations

  1. Departament de Ciències Fisiològiques II, IDIBELL-Universitat de Barcelona, Hospitalet de Llobregat, Spain

    C Campàs, A F Santidrián & J Gil

  2. Servei d'Hematologia, IDIBELL-Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain

    A Domingo

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  1. C Campàs
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  2. A F Santidrián
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  3. A Domingo
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  4. J Gil
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Correspondence to J Gil.

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Campàs, C., Santidrián, A., Domingo, A. et al. Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma. Leukemia 19, 292–294 (2005). https://doi.org/10.1038/sj.leu.2403593

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