Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation

Leukemia volume 19, pages 317–318 (2005)Cite this article

TO THE EDITOR

We read with great interest the recent clinical score developed by Gallardo et al1 for predicting the outcome after HLA-identical sibling donor allogeneic stem cell transplantation (SCT) in myeloid malignancies. However, we were somewhat surprised that cytogenetic variables were not taken into account as part of the analysis of SCT outcomes in acute myeloid leukemia (AML). Several studies over recent years have clearly defined cytogenetics as a major determinant of relapse risk and survival in AML, including post-SCT.2, 3 There is now general consensus that cytogenetic risk groups be used as the basis of selecting treatment strategies in AML, including allogeneic SCT.4, 5 In general, patients with good-risk cytogenetics are recommended for SCT only after relapse, and patients with poor-risk±intermediate-risk cytogenetics considered for HLA-identical sibling allogeneic SCT in first CR. Thus, we believe that analysis of SCT outcomes in AML without including cytogenetic information has limited generalised applicability.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Gallardo D, De la Camara R, Torres A, Brunet S, Jimenez A, Vallejo JC et al. Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation. Leukemia 2004; 18: 1031–1034.

    Article  CAS  Google Scholar 

  2. Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML10 trial. Blood 1998; 92: 2322–2333.

    CAS  Google Scholar 

  3. Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study. Blood 2000; 96: 4075–4083.

    CAS  Google Scholar 

  4. Burnett AK . Current controversies: which patients with acute myeloid leukaemia should receive a bone marrow transplantation? – an adult treater's view. Br J Haematol 2002; 118: 357–364.

    Article  Google Scholar 

  5. Giles FJ, Keating A, Goldstone AH, Avivi I, Willman CL, Kantarjian HM . Acute myeloid leukemia. Hematology (Am Soc Hematol Educ Program) 2002, 73–110.

Download references

Author information

Authors and Affiliations

  1. Department of Haematology, Royal Brisbane Hospital, Australia

    G A Kennedy, J Butler, R Western, J Morton, G Hill & S Durrant

  2. Queensland Institute of Medical Research, Australia

    G Hill

Authors
  1. G A Kennedy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Butler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Western
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Morton
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S Durrant
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G A Kennedy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kennedy, G., Butler, J., Western, R. et al. Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation. Leukemia 19, 317–318 (2005). https://doi.org/10.1038/sj.leu.2403549

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403549

Search

Advanced search

Quick links