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CD38 modifications in chronic lymphocytic leukemia: are they relevant?

Leukemia volume 18, pages 1733–1735 (2004)Cite this article

TO THE EDITOR

The expression of CD38 in chronic lymphocytic leukemia (CLL) has a strong predictive value, which is independent from the IgVH mutational status.1

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References

  1. Hamblin TJ, Orchard JA, Ibbotson RE, Davis Z, Thomas PW, Stevenson FK et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 2002; 99: 1023–1029.

    Article  CAS  PubMed  Google Scholar 

  2. Ibrahim S, Keating M, Do KA, O'Brien S, Huh YO, Jilani I et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001; 98: 181–186.

    Article  CAS  PubMed  Google Scholar 

  3. Krober A, Seiler T, Benner A, Bullinger L, Bruckle E, Lichter P et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100: 1410–1416.

    CAS  PubMed  Google Scholar 

  4. Chevallier P, Penther D, Avet-Loiseau H, Robillard N, Ifrah N, Mahe B et al. CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia. Br J Haematol 2002; 116: 142–150.

    Article  CAS  PubMed  Google Scholar 

  5. Chang CC, Cleveland RP . Conversion of CD38 and/or myeloid-associated marker expression status during the course of B-CLL: association with a change to an aggressive clinical course. Blood 2002; 100: 1106.

    Article  CAS  PubMed  Google Scholar 

  6. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840–1847.

    CAS  PubMed  Google Scholar 

  7. Durig J, Naschar M, Schmucker U, Renzing-Kohler K, Holter T, Huttmann A et al. CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia. Leukemia 2002; 16: 30–35.

    Article  CAS  PubMed  Google Scholar 

  8. D'Arena G, Nunziata G, Coppola G, Vigliotti ML, Tartarone A, Carpinelli N et al. CD38 expression does not change in B-cell chronic lymphocytic leukemia. Blood 2002; 100: 3052–3053.

    Article  CAS  PubMed  Google Scholar 

  9. Ghia P, Guida G, Stella S, Gottardi D, Geuna M, Strola G et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2003; 101: 1262–1269.

    Article  CAS  PubMed  Google Scholar 

  10. Pittner BT, Jelinek DF, Kay NE . CLL B cells with a bimodal CD38 expression pattern: persistence of bimodal populations despite effective therapy for B-CLL. Leukemia 2004; 18: 180–182.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported in part by Associazione Italiana per la Ricerca sul Cancro (AIRC), Progetto Oncologia CNR-MIUR and MURST 40%. CS is supported by FIRC, Milano.

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Authors and Affiliations

  1. Università degli Studi di Torino, Torino, Italy

    P Ghia & G Guida

  2. Institute for Cancer Research and Treatment (IRCC), Candiolo (TO), Italy

    P Ghia, G Guida & M Geuna

  3. Università Vita-Salute San Raffaele, Milano, Italy

    C Scielzo & F Caligaris-Cappio

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  1. P Ghia
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  2. G Guida
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Correspondence to P Ghia.

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Ghia, P., Guida, G., Scielzo, C. et al. CD38 modifications in chronic lymphocytic leukemia: are they relevant?. Leukemia 18, 1733–1735 (2004). https://doi.org/10.1038/sj.leu.2403504

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