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VH gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin

Leukemia volume 18, pages 1729–1732 (2004)Cite this article

TO THE EDITOR

Hairy cell leukemia (HCL) is characterized by homogeneous morphological, phenotypic and clinical features. Little is known about the genetic background or the cell of origin of this lymphoproliferative disorder. Recently, microarray1 and comparative expressed sequence hybridization (CESH)2 analysis of HCL showed a strikingly recurrent gene expression profile for this leukemia. This contrasts with the heterogeneous heavy-chain variable gene (VH) mutation status in HCL previously reported in 19 cases.3, 4, 5 To verify this issue, we analyzed the VH mutation status and VH gene usage of 20 HCL cases.

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Acknowledgements

This work was supported by Grants G.0362.01 and G.0223.03 from the Fund for Scientific Research (FWO), Flanders, Belgium. VV is a fellow of the FWO Flanders, Grant G.0362.01. We thank Miet Vanherck for her excellent technical assistance.

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Authors and Affiliations

  1. Division of Morphology and Molecular Pathology, Katholieke Universiteit Leuven, Leuven, Belgium

    V Vanhentenrijk & C D Wolf-Peeters

  2. Department of Pathology, The Norwegian Cancer Institute and Radiumhospital, University of Oslo, Oslo, Norway

    A Tierens

  3. Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium

    I Wlodarska

  4. Division of Hematology, Katholieke Universiteit Leuven, Leuven, Belgium

    G Verhoef

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  1. V Vanhentenrijk
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  5. C D Wolf-Peeters
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Correspondence to V Vanhentenrijk.

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Vanhentenrijk, V., Tierens, A., Wlodarska, I. et al. VH gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin. Leukemia 18, 1729–1732 (2004). https://doi.org/10.1038/sj.leu.2403503

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