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Extramedullary manifestation of a donor-derived acute myeloid leukemia in a liver transplant patient

Leukemia volume 18, pages 2050–2053 (2004)Cite this article

TO THE EDITOR

Improved patient care and new immunosuppressive therapy regimens result in better post-transplant survival and contribute to a growing number of transplantations. Hence, the frequency of post-transplant malignancies increases.1 Here, we describe a clinical case with unusual extramedullary presentation of an allograft-derived acute myeloid leukemia (AML) occurring 3 years after orthotopic liver transplantation (oLTX). HLA-typing, STR, cytogenetic and FICTION analyses proved this leukemia to be donor-derived.2 To our knowledge, this is the first report demonstrating allograft-localized donor-derived leukemia.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Charité- Universitätsmedizin Berlin, Germany

    M Subklewe & B Dörken

  2. Department of Forensic Medicine, Charité- Universitätsmedizin Berlin, Germany

    M Nagy

  3. LMU University of Munich, München, Germany

    C Schoch

  4. Department of Immunology, University Hospital Schleswig-Holstein, Kiel, Germany

    S Jenisch

  5. Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel, Germany

    R Siebert & S Gesk

  6. Department of Surgery, Charité-Universitätsmedizin, Berlin, Germany

    P Neuhaus

  7. Department of Hematology/Oncology, Universität Greifswald, Sauerbruchstraβe, Greifswald, Germany

    C A Schmidt

Authors
  1. M Subklewe
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  2. M Nagy
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  3. C Schoch
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  4. S Jenisch
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  5. R Siebert
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  6. S Gesk
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  7. P Neuhaus
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  8. B Dörken
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  9. C A Schmidt
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Corresponding author

Correspondence to C A Schmidt.

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Subklewe, M., Nagy, M., Schoch, C. et al. Extramedullary manifestation of a donor-derived acute myeloid leukemia in a liver transplant patient. Leukemia 18, 2050–2053 (2004). https://doi.org/10.1038/sj.leu.2403498

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  • DOI: https://doi.org/10.1038/sj.leu.2403498

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