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Myeloid antigen positive acute lymphoblastic leukemia with the Philadelphia translocation and a jumping translocation of 1q in a child

Leukemia volume 18, pages 1548–1550 (2004)Cite this article

TO THE EDITOR

Jumping translocations have been observed in many types of neoplasia, including hematopoietic cancers, where they are associated with poor prognosis.1 The most common chromosome region found in jumping translocations is the long arm of chromosome 1 (1q).1 The presence of the Philadelphia translocation (Ph+) in children with acute lymphoblastic leukemia (ALL) may also confer a poor prognosis in the presence of other high-risk features.2 This report is the first description of a child with a jumping translocation of 1q and Ph+ ALL. The tumor cells of this child also showed myeloid antigen expression, which occurs with high frequency in Ph+ ALL.3

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Acknowledgements

We thank the members of the Flow and Cytogenetics Labs at UNM/TriCore Reference Laboratories for their expert assistance in this analysis. We also thank Dr Julie Meyne of Los Alamos National Laboratories for the generous gift of the SOC-1 FISH probe.

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Authors and Affiliations

  1. Genzyme Genetics, Santa Fe, NM, USA

    K D Montgomery

  2. Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA

    S S Winter & J D Frost

  3. Department of Pathology, University of New Mexico, Albuquerque, NM, USA

    D Hardekopf, K Holt & K Foucar

  4. Department of Pediatrics, the University of Arizona, Tucson, AZ, USA

    M L Graham

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  1. K D Montgomery
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Correspondence to K D Montgomery.

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Montgomery, K., Winter, S., Frost, J. et al. Myeloid antigen positive acute lymphoblastic leukemia with the Philadelphia translocation and a jumping translocation of 1q in a child. Leukemia 18, 1548–1550 (2004). https://doi.org/10.1038/sj.leu.2403436

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