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Topoisomerase IIα as a prognostic factor in mantle cell lymphoma

Leukemia volume 18, pages 1347–1349 (2004)Cite this article

In a previous issue of Leukemia, Schrader et al1 evaluated the expression of topoisomerase IIα in mantle cell lymphoma, demonstrating its role as a proliferation marker and adverse prognostic factor.

Mantle cell lymphoma is a relatively new entity, which has been described separately only in the REAL and WHO classifications.2 This subtype comprises approximately 3–10% of all non-Hodgkin's lymphomas2 usually affecting older individuals with a median age of 65 years.2, 3 The disease frequently presents in Ann Arbor stages III and IV.2, 3 Bone marrow and subclinical gastrointestinal involvement are very common, while leukemic picture is encountered in more than 25% of the patients.

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References

  1. Schrader C, Meusers P, Brittinger G, Teymoortash A, Siebmann JU, Janssen D et al. Topoisomerase IIα expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome. Leukemia 2004; 18: 1200–1206.

    Article  CAS  Google Scholar 

  2. Swerdlow SH, Berger F, Isaackson PI, Müller-Hermelink HK, Nathwani BN, Piris MA et al. Mantle cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization Classification of Tumors: Pathology and Genetics. Tumors of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001, pp 168–170.

    Google Scholar 

  3. Anon . A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 1997; 89: 3909–3918.

    Google Scholar 

  4. Lenz G, Dreyling M, Hiddeman W . Mantle cell lymphoma: established therapeutic options and future directions. Ann Hematol 2004; 83: 71–77.

    Article  CAS  Google Scholar 

  5. Zucca E, Roggero E, Pinotti G, Pedrinis E, Capella C, Venco A et al. Patterns of survival in mantle cell lymphoma. Ann Oncol 1995; 6: 257–262.

    Article  CAS  Google Scholar 

  6. Khouri IF, Saliba RM, Okoroji GJ, Achonulu SA, Champlin RE . Long-term follow-up of autologous stem cell transplantation in patients with diffuse mantle cell lymphoma in first disease remission. The prognostic value of β2-microglobulin and the tumor score. Cancer 2003; 98: 2630–2635.

    Article  Google Scholar 

  7. Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD . Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 1997; 89: 2067–2078.

    CAS  PubMed  Google Scholar 

  8. Andersen NS, Jensen MK, de Nully Brown P, Geisler CH . A Danish population-based analysis of 105 mantle cell lymphoma patients: incidences, clinical features, response, survival and prognostic factors. Eur J Cancer 2002; 38: 401–408.

    Article  CAS  Google Scholar 

  9. Bosch F, Lopez-Guillermo A, Campo E, Ribera JM, Conde E, Piris MA et al. Mantle cell lymphoma. Presenting features, response to therapy, and prognostic factors. Cancer 1998; 82: 567–575.

    Article  CAS  Google Scholar 

  10. Samaha H, Dumontet C, Ketterer N, Moullet I, Thieblemont C, Bouafia F et al. Mantle cell lymphoma: a retrospective study of 121 cases. Leukemia 1998; 12: 1281–1287.

    Article  CAS  Google Scholar 

  11. Oinonen R, Fransilla K, Teerenhovi L, Lappalainen K, Elonen E . Mantle cell lymphoma: clinical features, treatment and prognosis of 94 patients. Eur J Cancer 1998; 34: 329–336.

    Article  CAS  Google Scholar 

  12. Zucca E, Roggero E, Pinotti G, Pedrinis E, Capella C, Venco A et al. Patterns of survival in mantle cell lymphoma. Ann Oncol 1995; 6: 257–262.

    Article  CAS  Google Scholar 

  13. Orchard J, Garand R, Davis Z, Babbage G, Sahota S, Matutes E et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 2003; 101: 4975–4981.

    Article  CAS  Google Scholar 

  14. Angelopoulou MK, Siakantaris MP, Vassilakopoulos TP, Kontopidou FN, Rassidakis G, Dimopoulou MN et al. The splenic form of mantle cell lymphoma. Eur J Haematol 2002; 68: 12–21.

    Article  Google Scholar 

  15. Campo E, Raffeld M, Jaffe ES . Mantle-cell lymphoma. Semin Hematol 1999; 36: 115–127.

    CAS  PubMed  Google Scholar 

  16. Greiner TC, Moynihan MJ, Chan WC, Lytle DM, Pedersen A, Anderson JR et al. p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 1996; 87: 4302–4310.

    CAS  PubMed  Google Scholar 

  17. Pinyol M, Hernandez L, Cazorla M, Balbin M, Jares P, Fernandez PL et al. Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphoma. Blood 1997; 89: 272–280.

    CAS  PubMed  Google Scholar 

  18. Korkolopoulou P, Angelopoulou M, Siakantari M, Mitropoulos F, Vassilakopoulos T, Zorzos H et al. Evaluation of DNA topoisomerase II expression provides independent prognostic information in non-Hodgkin's lymphomas. Histopathology 2001; 38: 45–53.

    Article  CAS  Google Scholar 

  19. Provencio M, Corbacho C, Salas C, Millan I, Espana P, Bonilla F et al. The topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Clin Cancer Res 2003; 9: 1406–1411.

    CAS  PubMed  Google Scholar 

  20. Vassilakopoulos TP, Doussis-Anagnostopoulou I, Angelopoulou MK, Siakantaris MP, Kittas C, Pangalis GA. Correspondence re: M. Provencio, et al. the topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Topoisomerase IIa expression in Hodgkin's lymphoma. Clin Cancer Res 2003; 9: 5430–5431.

    CAS  PubMed  Google Scholar 

  21. Kaufmann SH, Karp JE, Jones RJ, Miller CB, Schneider E, Zwelling LA et al. Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia. Blood 1994; 83: 517–530.

    CAS  PubMed  Google Scholar 

  22. Järvinen TAH, Holli K, Kuukasjärvi T, Isola JJ . Predictive value of topoisomerase IIα and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br J Cancer 1998; 77: 2267–2273.

    Article  Google Scholar 

  23. Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle-cell lymphoma. Cancer Cell 2003; 3: 185–197.

    Article  CAS  Google Scholar 

  24. Chiarle R, Budel LM, Skolnik J, Frizzera G, Chilosi M, Corato A et al. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 2000; 95: 619–626.

    CAS  PubMed  Google Scholar 

  25. Letestu R, Ugo V, Valensi F, Radford-Weiss I, Nataf J, Levy V et al. Prognostic impact of p27KIP1 expression in cyclin D1 positive lymphoproliferative disorders. Leukemia 2004; 18: 953–961.

    Article  CAS  Google Scholar 

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Author notes

  1. P Korkolopoulou and T P Vassilakopoulos: Both authors have equally contributed to the conception and writing of this manuscript

Authors and Affiliations

  1. Department of Pathology, National and Kapodistrian University of Athens, Greece

    P Korkolopoulou

  2. First Department of Internal Medicine, Haematology Section, National and Kapodistrian University of Athens, Greece

    T P Vassilakopoulos

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  1. P Korkolopoulou
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  2. T P Vassilakopoulos
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Correspondence to P Korkolopoulou.

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Korkolopoulou, P., Vassilakopoulos, T. Topoisomerase IIα as a prognostic factor in mantle cell lymphoma. Leukemia 18, 1347–1349 (2004). https://doi.org/10.1038/sj.leu.2403413

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