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All-trans retinoic acid reduced skin involvement of adult T-cell leukemia

Leukemia volume 18, pages 1159–1160 (2004)Cite this article

TO THE EDITOR

Adult T-cell leukemia (ATL) is a leukemia of mature peripheral T lymphocytes associated with human T-lymphotropic virus type I (HTLV-I). We previously reported that all-trans retinoic acid (ATRA) inhibited cell growth and induced apoptosis in HTLV-I (+) T-cell lines as well as fresh ATL cells obtained from ATL patients.1,2,3,4 Tsukasaki et al5 reported an interesting case in which ATRA induced complete remission for a patient with double hematological malignancies, acute promyelocytic leukemia and ATL. ATL is characterized by infiltration of various tissues by circulating ATL cells. Especially, skin lesions occur in 50% of ATL patients. In this study, we observed the effects of ATRA on skin involvement in ATL patients.

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References

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Authors and Affiliations

  1. Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine, Osaka, Japan

    Y Maeda, T Yamaguchi, S Ueda, H Miyazato, M Matsuda & A Kanamaru

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  1. Y Maeda
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  2. T Yamaguchi
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  3. S Ueda
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  4. H Miyazato
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  5. M Matsuda
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  6. A Kanamaru
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Correspondence to Y Maeda.

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Maeda, Y., Yamaguchi, T., Ueda, S. et al. All-trans retinoic acid reduced skin involvement of adult T-cell leukemia. Leukemia 18, 1159–1160 (2004). https://doi.org/10.1038/sj.leu.2403356

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