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Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group

Leukemia volume 18, pages 939–947 (2004)Cite this article

Abstract

Monosomy 7 or deletions of 7q are associated with many myeloid disorders; however, the significance of such abnormalities in childhood acute lymphoblastic leukemia (ALL) is unknown. Among 1880 children with ALL, 75 (4%) had losses involving chromosome 7, 16 (21%) with monosomy 7, 41 (55%) with losses of 7p (del(7p)), 16 (21%) with losses of 7q (del(7q)), and two (3%) with losses involving both arms. Patients with losses involving chromosome 7 were more likely to be ⩾10 years old, National Cancer Institute (NCI) poor risk, and hypodiploid than patients lacking this abnormality. Patients with or without these abnormalities had similar early response to induction therapy. Event-free survival (EFS) and survival for patients with monosomy 7 (P<0.0001 and P=0.0007, respectively) or del(7p) (P<0.0001 and P=0.0001, respectively), but not of patients with del(7q), were significantly worse than those of patients lacking these abnormalities. The poorer EFS was maintained after adjustment for a Philadelphia (Ph) chromosome, NCI risk status, ploidy, or an abnormal 9p. However, the impact on survival was not maintained for monosomy 7 after adjustment for a Ph. These results indicate that the critical region of loss of chromosome 7 in pediatric ALL may be on the p-arm.

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Author notes

  1. N A Heerema: Supported in part by research grants, including CCG Chairman's Grant No. CA-13539 and CA-60437, from the National Cancer Institute, National Institutes of Health

Authors and Affiliations

  1. The Ohio State University, Columbus, OH, USA

    N A Heerema

  2. University of Chicago, Chicago, IL, USA

    J B Nachman

  3. Children's Cancer Group, Arcadia, CA, USA

    H N Sather & M K La

  4. University of Michigan, Ann Arbor, MI, USA

    R Hutchinson

  5. Children's Hospital of Philadelphia, Philadelphia, PA, USA

    B J Lange

  6. Children's Hospitals and Clinics, Minneapolis, MN, USA

    B Bostrom

  7. Sloan Kettering Cancer Center, New York, NY, USA

    P G Steinherz

  8. University of California, Los Angles, CA, USA

    P S Gaynon

  9. CCG ALL Biology Reference Laboratory, Hughes Institute, St Paul, MN, USA

    F M Uckun

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  1. N A Heerema
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  2. J B Nachman
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  3. H N Sather
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  6. B J Lange
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Correspondence to N A Heerema.

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Heerema, N., Nachman, J., Sather, H. et al. Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group. Leukemia 18, 939–947 (2004). https://doi.org/10.1038/sj.leu.2403327

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