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Interleukin-3 receptor in acute leukemia

Leukemia volume 18, pages 219–226 (2004)Cite this article

Abstract

Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation of AMLs, and the overexpression of the IL-3Rα chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Furthermore, there is evidence that the IL-3Rα is a marker of leukemic stem cells, at variance with normal stem cells that are IL-3Rα−. Finally, the IL-3R may represent an important target for the development of new antileukemic drugs.

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  1. Department of Hematology and Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

    U Testa, R Riccioni, A Rossini & C Peschle

  2. Dipartimento di Biotecnologie Cellulari, Università “La Sapienza”, Rome, Italy

    D Diverio

  3. Cattedra e Divisione di Ematologia, Università Tor Vergata, Ospedale S Eugenio, Rome, Italy

    F Lo Coco

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Testa, U., Riccioni, R., Diverio, D. et al. Interleukin-3 receptor in acute leukemia. Leukemia 18, 219–226 (2004). https://doi.org/10.1038/sj.leu.2403224

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