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GST polymorphisms and occurrence of second neoplasms after treatment of childhood leukemia

Leukemia volume 17, pages 2540–2542 (2003)Cite this article

TO THE EDITOR

The marked improvement in the survival of children treated for cancer has focused increased attention on the long-term sequellae associated with contemporary intensive therapies. Second malignancies have been reported in patients treated for variety of childhood cancers, and have been associated with alkylating agents, topoisomerase inhibitors and radiation. Genetic differences in drug metabolizing enzymes may explain some of the variability in drug response.1 Thus, common genetic polymorphisms in drug metabolizing enzymes may result in impaired detoxification of chemotherapeutic agents, resulting in higher levels of genotoxic substrates that could contribute to increased DNA damage and subsequent development of second neoplasms.

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Authors and Affiliations

  1. Department of Pediatrics, Medical Centre Ljubljana, Ljubljana, Slovenia

    J Jazbec & M Debeljak

  2. The Children's Hospital of Philadelphia, Philadelphia, PA, USA

    R Aplenc

  3. Institute for Biochemistry, Faculty of Medicine, Ljubljana, Slovenia

    V Dolzan

  4. Institute of Oncology, Ljubljana, Slovenia

    B Jereb

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  1. J Jazbec
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  2. R Aplenc
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  4. M Debeljak
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Jazbec, J., Aplenc, R., Dolzan, V. et al. GST polymorphisms and occurrence of second neoplasms after treatment of childhood leukemia. Leukemia 17, 2540–2542 (2003). https://doi.org/10.1038/sj.leu.2403164

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  • DOI: https://doi.org/10.1038/sj.leu.2403164

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