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C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index

Leukemia volume 17, pages 471–472 (2003)Cite this article

Internal tandem duplications of FLT3 gene, that represents a strong prognostic factor for overall survival (OS) in AML patients younger than 60 years, seems a rare event in t(8;21) and inv(16)/t(16;16).1,2,3 By contrast, c-kit point mutations are more frequently described in core binding factor (CBF) leukemia; in this setting we previously reported the presence of both D816Y and D816V point mutations in six of 15 patients (40%)4,5,6 and Gari et al7 found an incidence of the c-kit proto-oncogene deletion plus insertion mutations of 33% among 21 patients with inv(16) and of 5% in patients with t(8;21). However little is known about their prognostic significance.

Recently a retrospective multicenter study on 154 adults and children with t(8;21) AML demonstrated that the WBC index (expressed as WBC × [% marrow blasts/100]) was the only prognostic factor for disease-free survival (DFS), complete remission (CR) duration and OS.8

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Authors and Affiliations

  1. Division of Hematology, Niguarda Hospital, Milan, Italy

    R Cairoli, G Grillo, A Tedeschi & E Morra

  2. Department of Biology and Genetics, Medical Faculty, University of Milan, Milan, Italy

    A Beghini, C B Ripamonti & L Larizza

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  1. R Cairoli
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  2. G Grillo
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Cairoli, R., Grillo, G., Beghini, A. et al. C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index. Leukemia 17, 471–472 (2003). https://doi.org/10.1038/sj.leu.2402795

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