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Isolated granulocytic sarcoma followed by acute myelogenous leukemia type FAB-M2 associated with inversion 16 and trisomies 9 and 22

Leukemia volume 16, pages 2458–2459 (2002)Cite this article

Granulocytic sarcoma (GS), also known as chloroma, are extramedullary tumors composed of immature myeloid cells. They have been described in a wide variety of anatomical sites, including breast, ovary, brain, gastrointestinal tract and skull.1,2 They occur at the onset of acute myelogenous leukemia (AML) or during its evolution. They may also be the first sign of acute transformation of myelodysplastic syndromes and chronic myeloproliferative disorders. They are rarely the first manifestation of AML. GS are observed in only 2 to 8% of AML, mainly of M2 morphology, although they have also been associated with M3, M4, M5, and M7 morphology.

A 37-year-old man was referred to our hospital in June 1999. He had a history of ascitis and intestinal occlusion due to three stenotic lesions of the jejunum. A large peritoneal mass was noted. The patient had surgery in March 1999 during which a partial resection of the proximal jejunum was performed. The histologic examination of the surgical piece was interpreted as a massive lymphomatous infiltration of the whole intestine wall. In May 1999, he had surgery again because of necrosis of the tumor with cutaneous fistula. A bone marrow biopsy and a complete blood count were normal. The patient received two courses of anti-lymphoma chemotherapy.

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Authors and Affiliations

  1. Faculté de Médecine, Université de Bretagne Occidentale, Brest, France

    F Morel, A Herry, C Berthou & M De Braekeleer

  2. Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest, France

    F Morel, A Herry, M-J Le Bris & M De Braekeleer

  3. Service d'Hématologie Biologique, CHU Morvan, Brest, France

    G Le Calvez & V Marion

  4. Service d'Hématologie Clinique, Institut d'Hématologie et de Cancérologie, CHU Morvan, Brest, France

    C Berthou

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Morel, F., Herry, A., Le Bris, MJ. et al. Isolated granulocytic sarcoma followed by acute myelogenous leukemia type FAB-M2 associated with inversion 16 and trisomies 9 and 22. Leukemia 16, 2458–2459 (2002). https://doi.org/10.1038/sj.leu.2402593

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